Kidney function during choline deficiency

Kratzing C.C., Perry J.J., Ellway C.P. and Wetzig G.A. (1972) Kidney function during choline deficiency. Pathology, 4 1: 53-59.

Author Kratzing C.C.
Perry J.J.
Ellway C.P.
Wetzig G.A.
Title Kidney function during choline deficiency
Journal name Pathology   Check publisher's open access policy
ISSN 1465-3931
Publication date 1972
Sub-type Article (original research)
Volume 4
Issue 1
Start page 53
End page 59
Total pages 7
Subject 2734 Pathology and Forensic Medicine
Abstract The relationship between kidney damage and hypertension caused by choline deficiency was studied in young male rats. Excretion of a test load of NaCI solution was used as a test of kidney function and it was found that the proportion of Na+ of the test load excreted in 4 hours decreased significantly as choline deficiency progressed. K+ excretion was also depressed by about 15 per cent. Administration of ethyl trichloracetate or α methyl dopa reduced the hypertension in choline deficient rats, with increased rate of Na+ excretion with former treatment and decreased rate of excretion with the latter. Regimes of partial immersion in water had no effect in excretion rate of Na+ but reduced hypertension. Hemicholinium-3 raised blood pressure of choline supplemented rats to levels similar to that of deficient but had no effect either on blood pressure of deficient or Na + excretion in supplemented or deficient rats. Metaraminol inhibited Na+ excretion in both supplemented and deficient rats.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
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Created: Tue, 14 Jun 2016, 03:51:12 EST by System User