Further characterization of the cells involved in leukocyte adherence inhibition with murine tumor extracts

Koppi T.A. and Halliday W.J. (1982) Further characterization of the cells involved in leukocyte adherence inhibition with murine tumor extracts. Cellular Immunology, 66 2: 394-406. doi:10.1016/0008-8749(82)90189-7


Author Koppi T.A.
Halliday W.J.
Title Further characterization of the cells involved in leukocyte adherence inhibition with murine tumor extracts
Journal name Cellular Immunology   Check publisher's open access policy
ISSN 1090-2163
Publication date 1982-01-15
Sub-type Article (original research)
DOI 10.1016/0008-8749(82)90189-7
Volume 66
Issue 2
Start page 394
End page 406
Total pages 13
Subject 1307 Cell Biology
2403 Immunology
Abstract Peritoneal cells from tumor-bearing CBA mice were depleted of either T lymphocytes (by treatment with anti-Thy-1.2 antiserum), lymphocytes with the Ly-1 marker (by anti-Ly-1.1 monoclonal antibody), or macrophages (by an adherence method). Depleted populations were compared with control populations for their ability to react with the corresponding tumor extract in the leukocyte adherence inhibition (LAI) assay. Direct and indirect assays were used, with emphasis on the latter which depends on the formation of a soluble mediator, leukocyte adherence inhibition factor (LAIF). Both Moloney sarcoma virus-induced tumors and transplanted methylcholanthrene-induced tumors were employed and gave similar results. LAI reactivity depended on lymphocytes with the Thy-1 and Ly-1 markers, and on macrophages (syngeneic or allogeneic). These T lymphocytes were shown to be the source of LAIF, the macrophages being required as accessory cells. T lymphocytes were also necessary in the LAIF-responsive indicator cell population.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 9 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 14 Jun 2016, 03:28:35 EST by System User