Another look at rejection in pig liver homografts

Battersby C., Egerton W.S., Balderson G., Kerr J.F. and Burnett W. (1974) Another look at rejection in pig liver homografts. Surgery, 76 4: 617-623.

Author Battersby C.
Egerton W.S.
Balderson G.
Kerr J.F.
Burnett W.
Title Another look at rejection in pig liver homografts
Journal name Surgery   Check publisher's open access policy
ISSN 0039-6060
Publication date 1974
Sub-type Article (original research)
Volume 76
Issue 4
Start page 617
End page 623
Total pages 7
Subject 2746 Surgery
Abstract Orthotopic liver homografting in 59 pigs was successful in producing survival beyond the immediate operative period in 29 animals. Survivors without immunosuppression were subjected to serial biopsy from 3 days to more than one year after transplantation. A composite picture of progressive histological changes in the group as well as in individuals has been built up. About 3 days after transplantation, there appeared in homografts (but not in autografts) progressive infiltration of the portal tracts by round cells, which was well established by the second postoperative week, and which was accompanied in severely affected animals by round-cell infiltration of the parenchyma, extensive death of hepatocytes by apoptosis, and canalicular bile stasis. The heavy round-cell infiltration coincided with the appearance of jaundice in about half the animals, and subsided spontaneously with the jaundice. By 4 weeks the lymphocytic infiltration was much less marked, but there developed a progressive fibrosis with disruption of the lobules and the appearance of regenerative nodules. This appeared to vary in speed of development and severity from animal to animal, but was present in most long-term survivors, despite apparent clinical and biochemical evidence of well being. Two long-term survivors died with biochemical and pathological evidence of progressive hepatocellular insufficiency. While acute rejection rarely causes death in this species, changes suggestive of chronic rejection occur in most animals and may cause death from liver failure.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
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