Immunosuppressive activity in serum from mice infected with Nematospiroides dubius following passive serum transfer

Dobson C. and Cayzer C.J.R. (1982) Immunosuppressive activity in serum from mice infected with Nematospiroides dubius following passive serum transfer. International Journal for Parasitology, 12 6: 561-566. doi:10.1016/0020-7519(82)90052-2


Author Dobson C.
Cayzer C.J.R.
Title Immunosuppressive activity in serum from mice infected with Nematospiroides dubius following passive serum transfer
Journal name International Journal for Parasitology   Check publisher's open access policy
ISSN 0020-7519
Publication date 1982
Sub-type Article (original research)
DOI 10.1016/0020-7519(82)90052-2
Volume 12
Issue 6
Start page 561
End page 566
Total pages 6
Subject 2405 Parasitology
2725 Infectious Diseases
Abstract Dobson C. and Cayzer C. J. R. 1982. Immunosuppressive activity in serum from mice infected with Nematospiroides dubius following passive serum transfer. International Journal for Parasitology 12: 561-566. Anti-N. dubius antibody titres increased with time after primary and secondary infections with 100 larvae in mice and 4 days after anthelmintic termination of a 28 day infection. Mice injected with serum from infected mice harboured fewer, smaller worms with reduced fecundities compared with control mice; the difference was greater with serum from donors given two compared with those given one infection. Mice injected with serum from donors infected for 14 days had fewer N. dubius than recipients of serum from mice infected for 28 days. Serum taken from mice 4 days after termination of a primary infection of 28 days duration was more protective when passively transferred to mice than serum from mice infected for 28 days. Serum from mice infected with 50 N. dubius larvae was more protective than serum, with a higher anti-N. dubius antibody titre, from, mice infected with 400 larvae. These observations are discussed in relation to immunosuppressive activities in the donated serum and associated with N. dubius.
Keyword immunosuppression
mice
Nematospiroides dubius
passive serum immunity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 14 Jun 2016, 01:57:35 EST by System User