The effects of amphotericin b, fluconazole and miconazole on neutrophil and lymphocyte function in a Guinea pig model

Drummond D.C., Wong C.W., Whitman L.M. and Mccormack J.G. (1995) The effects of amphotericin b, fluconazole and miconazole on neutrophil and lymphocyte function in a Guinea pig model. Journal of Antimicrobial Chemotherapy, 36 2: 375-384. doi:10.1093/jac/36.2.375


Author Drummond D.C.
Wong C.W.
Whitman L.M.
Mccormack J.G.
Title The effects of amphotericin b, fluconazole and miconazole on neutrophil and lymphocyte function in a Guinea pig model
Journal name Journal of Antimicrobial Chemotherapy   Check publisher's open access policy
ISSN 0305-7453
Publication date 1995
Sub-type Article (original research)
DOI 10.1093/jac/36.2.375
Volume 36
Issue 2
Start page 375
End page 384
Total pages 10
Subject 1804 Statistics, Probability and Uncertainty
2604 Applied Mathematics
2737 Physiology (medical)
2725 Infectious Diseases
2736 Pharmacology (medical)
3004 Pharmacology
2404 Microbiology
Abstract We studied the effects of amphotericin B, fluconazole and miconazole on Guinea pig neutrophil and lymphocyte function. Neutrophil adherence, chemotaxis, and deoxyglucose uptake and mitogen-induced lymphocyte proliferation were examined. The drugs were administered intraperitoneally in varying dosages based on those used therapeutically, either as a single infusion or daily for 3 days. Miconazole at high dosage (60 mg/kg) suppressed mitogen-induced lymphocyte proliferation, otherwise a single dose of any of the drugs had no effect on neutrophil or lymphocyte function irrespective of concentration used. Variable stimulative or suppressive effects on neutrophil and lymphocyte function were observed after three daily doses of each drug, but there was no dose-response pattern and the effects were erratic. The data show that, contrary to previous findings in vitro, amphotericin B, fluconazole and miconazole were not consistently immunosuppressive in vivo in this animal model.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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