Comparison of the biological, biophysical and antigenic properties of four strains of infectious bovine rhinotracheitis herpesvirus

Bagust T.J. (1972) Comparison of the biological, biophysical and antigenic properties of four strains of infectious bovine rhinotracheitis herpesvirus. Journal of Comparative Pathology, 82 4: 365-374. doi:10.1016/0021-9975(72)90035-7


Author Bagust T.J.
Title Comparison of the biological, biophysical and antigenic properties of four strains of infectious bovine rhinotracheitis herpesvirus
Journal name Journal of Comparative Pathology   Check publisher's open access policy
ISSN 0021-9975
Publication date 1972
Sub-type Article (original research)
DOI 10.1016/0021-9975(72)90035-7
Volume 82
Issue 4
Start page 365
End page 374
Total pages 10
Subject 1103 Clinical Sciences
Abstract Four Australian strains of infectious bovine rhinotracheitis (IBR) herpesvirus, isolated from rhinitis, vulvovaginitis and meningo-encephalitis were examined. In experimental calves, all strains of virus produced rhinitis, conjunctivitis and vulvovaginitis when applied to these surfaces, but only the isolate from meningo-encephalitis (N569) produced a fatal meningo-encephalitis after intranasal infection and a meningitis-like disease after intravaginal infection. N569 virus instilled on the conjunctiva produced a temperature rise and virus proliferation in the nasal cavity, but not meningo-encephalitis. Pre-existing serum neutralizing antibody to heterologous strains of IBR virus protected calves challenged intranasally with N569 virus. The 4 strains of IBR virus showed no differences in thermostability at 40°C. or in buoyant density of infectious particles, but the N569 strain formed smaller plaques under agar overlay. Rabbit hyperimmune serums produced against each virus strain detected no antigenic differences between isolates from rhinitis and vulvovaginitis, but the antigenic nature of N569 virus was significantly different (P < 0·05) from the other 3 strains of IBR virus.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 14 Jun 2016, 01:52:08 EST by System User