N-acetylneuraminic acid and hostile mucus infertility

Polak B. and Daunter B. (1987) N-acetylneuraminic acid and hostile mucus infertility. European Journal of Obstetrics and Gynecology and Reproductive Biology, 26 1: 57-68. doi:10.1016/0028-2243(87)90009-8


Author Polak B.
Daunter B.
Title N-acetylneuraminic acid and hostile mucus infertility
Journal name European Journal of Obstetrics and Gynecology and Reproductive Biology   Check publisher's open access policy
ISSN 0028-2243
Publication date 1987
Sub-type Article (original research)
DOI 10.1016/0028-2243(87)90009-8
Volume 26
Issue 1
Start page 57
End page 68
Total pages 12
Subject 2729 Obstetrics and Gynaecology
2743 Reproductive Medicine
Abstract A total of 39 samples of hostile mucus, as defined by postcoital examination, were examined for N-acetylneuraminic acid (NANA) deficiency, as measured by the enzymatic addition of NANA, spermatozoal penetration and immobilization. Only 56.7% of the mucus samples were deficient in NANA and this did not correlate with spermatozoal penetration or immobilization, which were negatively correlated. Thus, as the spermatozoal hostility in the mucus decreases, spermatozoal penetration increases. This finding also applies to hostile mucus not deficient in NANA. In contrast, resialylation of NANA hostile mucus, deficient and not deficient in NANA, although not enhancing spermatozoal penetration, did reduce spermatozoal immobilization. Thus, components of the mucus deficient in NANA and/or the lack of unbound NANA may contribute to mucus hostility, but it is not the only hostile factor. In addition, SEM studies of NANA-deficient mucin before and after resialylation were shown to have similar structures. Hence ultrastructural changes are not apparent in NANA-deficient mucin, and this supports the previous finding that NANA deficiency does not impede spermatozoal penetration. The spermatozoa from the husbands of the infertile couples formed three distinct groups in terms of spermatozoal penetration and immobilization in normal donor mucus. One group demonstrated normal levels of spermatozoal penetration and immobilization in donor mucus. A second group was demonstrable in which spermatozoal penetration was similar to that in the wife's hostile mucus, but had a normal level of spermatozoal immobilization. In the third group, both spermatozoal penetration and immobilization in donor mucus were similar to that in the wife's hostile mucus. The results demonstrate that not all hostile mucus is deficient in NANA, and that other unknown factors are involved. In addition, there are also male factors which may impede spermatozoal penetration and/or result in the inability of the spermatozoa to survive in normal donor mucus.
Keyword Cervical mucus
Infertility
N-Acetylneuraminic acid
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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