An ultrastructural study of meconium corpuscles in human foetal colon

Williams L. and Bell L. (1985) An ultrastructural study of meconium corpuscles in human foetal colon. Anatomy and Embryology, 171 3: 373-376. doi:10.1007/BF00347026


Author Williams L.
Bell L.
Title An ultrastructural study of meconium corpuscles in human foetal colon
Journal name Anatomy and Embryology   Check publisher's open access policy
ISSN 0340-2061
Publication date 1985
Sub-type Article (original research)
DOI 10.1007/BF00347026
Volume 171
Issue 3
Start page 373
End page 376
Total pages 4
Publisher Springer-Verlag
Subject 2710 Embryology
2702 Anatomy
1309 Developmental Biology
1307 Cell Biology
Abstract In human foetal colon meconium corpuscles were observed in the colonic epithelium during the stage of secondary lumina development and enlargement. Transmission electron microscopy of these specimens revealed inclusion bodies in the superficial and deeper layers of the epithelium. Many of the membrane-bounded inclusion bodies contained well-preserved organelles and some inclusions contained nuclear fragments. There was evidence of nuclear fragmentation with condensed chromatin arranged in crescentic caps. The ultrastructural observations are typical of apoptosis, a mode of cell death first described in 1972 by Kerr and colleagues. Thus, meconium corpuscles are apoptotic bodies found as a result of the deletion of healthy normal cells during the reshaping and development of organs.
Keyword Apoptosis
Electron microscopy
Foetal intestine
Meconium corpuscles
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 14 Jun 2016, 01:10:33 EST by System User