The molecular revolution in the development of vaccines against ectoparasites

Willadsen P. (2001) The molecular revolution in the development of vaccines against ectoparasites. Veterinary Parasitology, 101 3-4: 353-367. doi:10.1016/S0304-4017(01)00560-X


Author Willadsen P.
Title The molecular revolution in the development of vaccines against ectoparasites
Journal name Veterinary Parasitology   Check publisher's open access policy
ISSN 0304-4017
Publication date 2001-11-22
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0304-4017(01)00560-X
Volume 101
Issue 3-4
Start page 353
End page 367
Total pages 15
Subject 1103 Clinical Sciences
2405 Parasitology
3400 Veterinary
Abstract Over the last decade, the application of a spectrum of molecular techniques has begun to revolutionise our understanding of protective immune responses to ectoparasites and the targets for those responses. The catalogue of potential and actual protective antigens characterised in detail is slowly expanding. The validity of regarding such antigens as generic and capable of cross-species protection is being explored. The immune interactions between host and parasite are being studied at a molecular rather than cellular level. All this should contribute to the eventual development of a range of recombinant vaccines, though important scientific limitations remain. These range from the innate susceptibility of individual parasite species to immunological attack, which can only be assessed on a case by case basis, to our ability to produce the desired recombinant antigens and to elicit and maintain the necessary immunological responses.
Keyword Antigen
Ectoparasite
Immunisation
Myiasis
Tick
Vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import
 
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Created: Tue, 14 Jun 2016, 00:48:39 EST by System User