Increased NMDA-induced excitability during ethanol withdrawal: a behavioural and histological study

Davidson M., Shanley B. and Wilce P. (1995) Increased NMDA-induced excitability during ethanol withdrawal: a behavioural and histological study. Brain Research, 674 1: 91-96. doi:10.1016/0006-8993(94)01440-S


Author Davidson M.
Shanley B.
Wilce P.
Title Increased NMDA-induced excitability during ethanol withdrawal: a behavioural and histological study
Journal name Brain Research   Check publisher's open access policy
ISSN 0006-8993
Publication date 1995-03-13
Sub-type Article (original research)
DOI 10.1016/0006-8993(94)01440-S
Volume 674
Issue 1
Start page 91
End page 96
Total pages 6
Subject 1309 Developmental Biology
1312 Molecular Biology
2728 Clinical Neurology
2800 Neuroscience
Abstract Intrahippocampal injections ofN-methyl-d-aspartic acid (NMDA) leads to neurodegeneration in a dose-dependent manner. Chronic administration of ethanol to animals leads to CNS tolerance and dependence. Hyperexcitability following ethanol withdrawal is thought to be related to increased sensitivity of the NMDA receptors. The purpose of this study was to investigate this predisposition to hyperexcitability by intrahippocampal injection of low doses of NMDA. Using control and ethanol-withdrawn male Wistar rats, behavioural indices were determined immediately after injection and morphological damage was assessed after a period of recovery. There was significantly increased hyperactivity in the ethanol-treated rats immediately after injection. Morphological damage resulting from 5 nmol of NMDA was significantly greater in the CA3 region of the hippocampus in these animals. These data support the hypothesis that ethanol dependence and subsequent withdrawal is associated with increased sensitivity to NMDA which may underlie ethanol withdrawal-associated brain damage.
Keyword Alcohol withdrawal
Ethanol
Excitotoxicity
N-Methyl-d-aspartate
Rat hippocampus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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