Feeling hot, feeling cold: TRP channels - a great story unfolds

Vetter, Irina, Kym, Philip R. and Szallasi, Arpad (2015) Feeling hot, feeling cold: TRP channels - a great story unfolds. Temperature, 2 2: 150-151. doi:10.1080/23328940.2015.1047721


Author Vetter, Irina
Kym, Philip R.
Szallasi, Arpad
Title Feeling hot, feeling cold: TRP channels - a great story unfolds
Journal name Temperature   Check publisher's open access policy
ISSN 2332-8940
2332-8959
Publication date 2015
Sub-type Editorial
DOI 10.1080/23328940.2015.1047721
Open Access Status Not Open Access
Volume 2
Issue 2
Start page 150
End page 151
Total pages 2
Place of publication Philadelphia, PA United States
Publisher Taylor & Francis
Language eng
Abstract This editorial is about the roles that TRP channels play in heat and cold sensation and body temperature regulation. These roles may be exploited for therapeutic purposes (indeed, drugs targeting TRPV1, TRPA1 and TRPM8 channels are currently undergoing clinical trials for indications that range from pain through chronic cough and overactive bladder to cancer) or, conversely, may limit drug development (for example, several TRPV1 antagonists were withdrawn from clinical trials due to the hyperthermic reaction that they caused). In the future, modulation of thermosensitive TRP channels may ultimately find application in the treatment not only of pain, but also itch, stroke, asthma, and metabolic disorders. Of the multitude of targets involved in temperature sensation and body temperature regulation, why TRP channels? And why now?
Keyword Capsaicin
Temperature-sensitive TRP channels ("thermoTRPs")
The capsaicin receptor TRPV1
TRPA1
TRPM3
TRPM8
TRP
Transient receptor potential
TRPV1
Transient receptor potential vanilloid 1
TRPA1
Transient receptor potential ankyrin 1
TRPM8
Transient receptor potential melastatin 8
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Editorial
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Mon, 13 Jun 2016, 11:45:20 EST by Susan Allen on behalf of Institute for Molecular Bioscience