Mice lacking programmed cell death-1 show a role for CD8+ T cells in long-term immunity against blood-stage malaria

Horne-Debets, Joshua M., Karunarathne, Deshapriya S., Faleiro, Rebecca J., Poh, Chek Meng, Renia, Laurent and Wykes, Michelle N. (2016) Mice lacking programmed cell death-1 show a role for CD8+ T cells in long-term immunity against blood-stage malaria. Scientific Reports, 6 . doi:10.1038/srep26210


Author Horne-Debets, Joshua M.
Karunarathne, Deshapriya S.
Faleiro, Rebecca J.
Poh, Chek Meng
Renia, Laurent
Wykes, Michelle N.
Title Mice lacking programmed cell death-1 show a role for CD8+ T cells in long-term immunity against blood-stage malaria
Formatted title
Mice lacking programmed cell death-1 show a role for CD8+ T cells in long-term immunity against blood-stage malaria
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2016-05-24
Year available 2016
Sub-type Article (original research)
DOI 10.1038/srep26210
Open Access Status DOI
Volume 6
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2017
Language eng
Formatted abstract
Even after years of experiencing malaria, caused by infection with Plasmodium species, individuals still have incomplete immunity and develop low-density parasitemia on re-infection. Previous studies using the P. chabaudi (Pch) mouse model to understand the reason for chronic malaria, found that mice with a deletion of programmed cell death-1 (PD-1KO) generate sterile immunity unlike wild type (WT) mice. Here we investigated if the mechanism underlying this defect during acute immunity also impacts on long-term immunity. We infected WT and PD-1KO mice with Pch-malaria and measured protection as well as immune responses against re-infections, 15 or 20 weeks after the original infection had cleared. WT mice showed approximately 1% parasitemia compared to sterile immunity in PD-1KO mice on re-infection. An examination of the mechanisms of immunity behind this long-term protection in PD-1KO mice showed a key role for parasite-specific CD8+ T cells even when CD4+ T cells and B cells responded to re-infection. These studies indicate that long-term CD8+ T cell-meditated protection requires consideration for future malaria vaccine design, as part of a multi-cell type response.
Keyword Malaria
Plasmodium
Blood-stage malaria
Immunity
Malaria-related mortality
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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