A study of the mechanism of absorption of orally administered amoxycillin in humans

Chulavatnatol, Suvatna (1994). A study of the mechanism of absorption of orally administered amoxycillin in humans PhD Thesis, School of Pharmacy, University of Queensland. doi:10.14264/uql.2016.416

       
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Author Chulavatnatol, Suvatna
Thesis Title A study of the mechanism of absorption of orally administered amoxycillin in humans
School, Centre or Institute School of Pharmacy
Institution University of Queensland
DOI 10.14264/uql.2016.416
Publication date 1994-01-01
Thesis type PhD Thesis
Supervisor B.G. Charles
Total pages 372
Language eng
Subjects 1115 Pharmacology and Pharmaceutical Sciences
Formatted abstract
The mechanism of absorption of orally administered amoxycillin in humans with special reference to the peptide absorption pathway was investigated in this thesis. The aims of this research were (i) to develop sensitive, specific and precise analytical methods based on high-performance liquid chromatography (HPLC) for the quantitation of amoxycillin in plasma and urine; (ii) to study the pharmacokinetics of single oral doses of amoxycillin in healthy subjects; (iii) to study the mechanism of amoxycillin absorption based on the putative peptide absorption pathway. 

Two robust, sensitive, specific and precise HPLC assays were developed for the measurement of amoxycillin in plasma and urine. The plasma assay allowed the quantitation of amoxycillin concentrations with a minimum quantifiable concentration of 03 mg/l which enabled studies of the kinetics of absorption following the oral administration of a 250 mg/5 ml suspension. The amoxycillin assay for urine samples had minimum quantifiable concentration of 7.5 mg/1 and was applied in the study of dose-dependent absorption kinetics of amoxycillin, and to investigate the effect of glycyl-peptides on amoxycillin absorption.

 Absorption kinetics of amoxycillin following a single, oral dose of 250 mg/5 ml suspension in 18 healthy, young subjects in the present clinical study were compared with the analysis of raw data from the literature in which doses of 500 mg, 750 mg and 1000 mg were administered. A 1-compartment model with zero-order absorption kinetics (including a lag time) described amoxycillin absorption kinetics in the majority of cases.    ..........................................
Keyword Amoxicillin
Pharmacokinetics
Drugs -- Metabolism
Additional Notes Spine title: Mechanism of absorption of amoxycillin in humans

Document type: Thesis
Collection: UQ Theses (RHD) - UQ staff and students only
 
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