Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica

Ariki, Nathanial K., Muñoz, Lisa E., Armitage, Elizabeth L., Goodstein, Francesca R., George, Kathryn G, Smith, Vanessa L., Vetter, Irina, Herzig, Volker, King, Glenn F. and Loening, Nikolaus M. (2016) Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica. PLoS One, 11 5: . doi:10.1371/journal.pone.0156291


Author Ariki, Nathanial K.
Muñoz, Lisa E.
Armitage, Elizabeth L.
Goodstein, Francesca R.
George, Kathryn G
Smith, Vanessa L.
Vetter, Irina
Herzig, Volker
King, Glenn F.
Loening, Nikolaus M.
Title Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica
Formatted title
Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2016-05-26
Year available 2016
Sub-type Article (original research)
DOI 10.1371/journal.pone.0156291
Open Access Status DOI
Volume 11
Issue 5
Total pages 16
Place of publication San Francisco, United States
Publisher Public Library of Science
Collection year 2017
Language eng
Formatted abstract
We present the solution-state NMR structures and preliminary functional characterizations of three venom peptides identified from the spitting spider Scytodes thoracica. Despite little sequence identity to other venom peptides, structural characterization reveals that these peptides contain an inhibitor cystine knot motif common to many venom peptides. These are the first structures for any peptide or protein from spiders of the Scytodidae family. Many venom peptides target neuronal ion channels or receptors. However, we have not been able to determine the target of these Scytodes peptides so we can only state with certainty the channels and receptors that they do not target.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 07 Jun 2016, 14:57:15 EST by Susan Allen on behalf of Institute for Molecular Bioscience