Prevalence of Skin Cancer and Related Skin Tumors in High-Risk Kidney and Liver Transplant Recipients in Queensland, Australia

Iannacone, Michelle R., Sinnya, Sudipta, Pandeya, Nirmala, Isbel, Nikky, Campbell, Scott, Fawcett, Jonathan, Soyer, Peter H., Ferguson, Lisa, Davis, Marcia, Whiteman, David C., Green, Adèle C. and for the STAR Study (2016) Prevalence of Skin Cancer and Related Skin Tumors in High-Risk Kidney and Liver Transplant Recipients in Queensland, Australia. Journal of Investigative Dermatology, 136 7: 1382-1386. doi:10.1016/j.jid.2016.02.804


Author Iannacone, Michelle R.
Sinnya, Sudipta
Pandeya, Nirmala
Isbel, Nikky
Campbell, Scott
Fawcett, Jonathan
Soyer, Peter H.
Ferguson, Lisa
Davis, Marcia
Whiteman, David C.
Green, Adèle C.
for the STAR Study
Title Prevalence of Skin Cancer and Related Skin Tumors in High-Risk Kidney and Liver Transplant Recipients in Queensland, Australia
Journal name Journal of Investigative Dermatology   Check publisher's open access policy
ISSN 1523-1747
0022-202X
Publication date 2016-03-09
Sub-type Article (original research)
DOI 10.1016/j.jid.2016.02.804
Open Access Status Not Open Access
Volume 136
Issue 7
Start page 1382
End page 1386
Total pages 5
Place of publication London United Kingdom
Publisher Nature Publishing Group
Collection year 2017
Language eng
Abstract The increased skin cancer incidence in organ transplant recipients is well-known, but the skin cancer burden at any one time is unknown. Our objective was to estimate the period prevalence of untreated skin malignancy and actinic keratoses in high-risk kidney and liver transplant recipients and to assess associated factors. Organ transplant recipients underwent full skin examinations by dermatologically trained physicians. The proportion of examined organ transplant recipients with histopathologically confirmed skin cancer in the 3-month baseline period was estimated. Prevalence ratios with 95% confidence intervals indicated significant associations. Of 495 high-risk organ transplant recipients (average age ¼ 54 years, time immunosuppressed ¼ 8.9 years), 135 (27%) had basal cell carcinoma, squamous cell carcinoma or Bowen’s disease (intraepidermal carcinoma) present and confirmed in the baseline period, with respective prevalence proportions of 10%, 11%, and 18% in kidney transplant recipients and 10%, 9%, and 13% in liver transplant recipients. Over 80% had actinic keratosis present, with approximately 30% having 5 or more actinic keratoses. Organ transplant recipients with the highest skin cancer burden were Australian born, were fair skinned (prevalence ratio ¼ 1.61, 95% confidence interval ¼ [1.07, 2.43]), reported past skin cancer (prevalence ratio ¼3.39, 95% confidence interval ¼ [1.93, 5.95]), and were receiving the most frequent skin checks (prevalence ratio ¼ 1.76, 95% confidence interval ¼ [1.15, 2.70]). In conclusion, high-risk organ transplant recipients carry a substantial measurable skin cancer burden at any given time and require frequent review through easily accessible, specialized services.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Tue, 07 Jun 2016, 11:29:16 EST by Professor Peter Soyer on behalf of School of Medicine