Vitamin D pathway gene polymorphisms and keratinocyte cancers: a nested case-control study and meta-analysis

Von Schuckmann, Lena A., Law, Matthew H., Montgomery, Grant W., Green, Adele C. and van der Pols, Jolieke C. (2016) Vitamin D pathway gene polymorphisms and keratinocyte cancers: a nested case-control study and meta-analysis. Anticancer Research, 36 5: 2145-2152.

Author Von Schuckmann, Lena A.
Law, Matthew H.
Montgomery, Grant W.
Green, Adele C.
van der Pols, Jolieke C.
Title Vitamin D pathway gene polymorphisms and keratinocyte cancers: a nested case-control study and meta-analysis
Journal name Anticancer Research   Check publisher's open access policy
ISSN 0250-7005
1791-7530
Publication date 2016-05
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 36
Issue 5
Start page 2145
End page 2152
Total pages 8
Place of publication Kapandriti Attica, Attiki, Greece
Publisher International Institute of Anticancer Research
Collection year 2017
Language eng
Formatted abstract
Background: The vitamin D endocrine system is implicated in skin carcinogenesis and polymorphisms in genes associated with the vitamin D receptor (VDR) gene may alter the risk of keratinocyte cancers (basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)).

Materials and Methods: In a nested case-control study of 1,124 adults, we investigated associations between polymorphisms in VDR-related pathways and incident keratinocyte cancers during 11 years of follow-up using adjusted multivariate regression analysis. We also performed a meta-analysis of rs2228570, rs7975232, rs1544410 and rs739837 polymorphisms.

Results: A total of 286 BCCs and 161 SCCs were newly-diagnosed during follow-up. Participants with rs2228570 and rs927650 recessive genotypes had a decreased risk of SCC (odds ratio (OR)=0.34, 95% confidence interval (CI)=0.17-0.68; OR=0.48, CI=0.27-0.84, respectively). Meta-analysis showed a lower SCC risk in rs1544410 recessive genotypes (summary OR (SOR)=0.74, CI=0.53-0.94), while rs7975232 and rs739837 recessive genotypes were associated with a decreased BCC risk (SOR=0.74, CI=0.56-0.98; SOR=0.65, CI=0.43-0.88).

Conclusion: Our meta-analysis indicated that vitamin D receptor polymorphisms may be associated with the risk of keratinocyte cancers.
Keyword Vitamin D pathway
Polymorphisms
Keratinocyte cancers
Squamous cell carcinoma
Basal cell carcinoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Public Health Publications
 
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