Preparation and characterization of spray-dried gelatin microspheres encapsulating ganciclovir

Tran, Tuan Hiep, Ramasamy, Thiruganesh, Poudel, Bijay Kumar, Marasini, Nirmal, Moon, Bo Kyung, Cho, Hyuk Jun, Choi, Han-Gon, Yong, Chul Soon and Kim, Jong Oh (2014) Preparation and characterization of spray-dried gelatin microspheres encapsulating ganciclovir. Macromolecular Research, 22 2: 124-130. doi:10.1007/s13233-014-2018-9

Author Tran, Tuan Hiep
Ramasamy, Thiruganesh
Poudel, Bijay Kumar
Marasini, Nirmal
Moon, Bo Kyung
Cho, Hyuk Jun
Choi, Han-Gon
Yong, Chul Soon
Kim, Jong Oh
Title Preparation and characterization of spray-dried gelatin microspheres encapsulating ganciclovir
Journal name Macromolecular Research   Check publisher's open access policy
ISSN 1598-5032
Publication date 2014-02
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s13233-014-2018-9
Open Access Status Not Open Access
Volume 22
Issue 2
Start page 124
End page 130
Total pages 7
Place of publication Seoul, Korea, Republic of
Publisher Hangug Gobunja Haghoi / Polymer Society of Korea
Language eng
Formatted abstract
The aim of this study was to prepare ganciclovir (GCV)-loaded cross-linked gelatin microspheres by spray-drying method. The microspheres were characterized in terms of particle size, surface morphology, loading efficiency, thermal behavior, physical characteristics, swelling properties, and the release profile in vitro. The major process and formulation parameters were optimized to obtain smaller particles with high loading capacity. The physical state examination confirmed the molecular-level dispersion of drug in the polymer. The loading efficiency determined by high-performance liquid chromatography (HPLC) was around 68%. The in vitro release experiments revealed that the GCV released from the gelatin microspheres was related to the extent of swelling, which was proportional to the drug-to-polymer ratio. These results suggest that cross-linked gelatin microspheres could be a suitable drug-delivery system for GCV.
Keyword Cross-linking
Gelatin microspheres
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
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Created: Sat, 04 Jun 2016, 12:28:06 EST by Nirmal Marasini on behalf of Learning and Research Services (UQ Library)