Application of Box-Behnken design in the preparation and optimization of fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS)

Lee, Dong Won, Marasini, Nirmal, Poudel, Bijay Kumar, Kim, Jeong Hwan, Cho, Hyuk Jun, Moon, Bo Kyung, Choi, Han-Gon, Yong, Chul Soon and Kim, Jong Oh (2014) Application of Box-Behnken design in the preparation and optimization of fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS). Journal of Microencapsulation, 31 1: 31-40. doi:10.3109/02652048.2013.805837


Author Lee, Dong Won
Marasini, Nirmal
Poudel, Bijay Kumar
Kim, Jeong Hwan
Cho, Hyuk Jun
Moon, Bo Kyung
Choi, Han-Gon
Yong, Chul Soon
Kim, Jong Oh
Title Application of Box-Behnken design in the preparation and optimization of fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS)
Journal name Journal of Microencapsulation   Check publisher's open access policy
ISSN 0265-2048
1464-5246
Publication date 2014
Year available 2013
Sub-type Article (original research)
DOI 10.3109/02652048.2013.805837
Open Access Status Not Open Access
Volume 31
Issue 1
Start page 31
End page 40
Total pages 10
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Language eng
Formatted abstract
This study was designed to optimize a fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS) by using a response surface methodology. Box-Behnken design (BBD) and its desirability function were used to optimize the SMEDDS. The independent factors were the amounts of Labrafil M 1944 CS, Labrasol, and Capryol PGMC and the dependent variables were droplet size, cumulative percentage of drug released in 30min and equilibrium solubility of fenofibrate in SMEDDS. Various response surface graphs were used to understand the effects of each factor, and the desirability function was then adjusted to optimize SMEDDS formulation. The experimental values of optimized formulation were in close agreement with predicted values. Furthermore, in vivo pharmacokinetic study of the optimized formulation showed significant increase in relative oral bioavailability compared to that of the powder suspension. In conclusion, the BBD demonstrated its effectiveness in optimizing the SMEDDS formulation and in identifying the effects of formulation variables.
Keyword Box-Behnken design
Desirability function
Fenofibrate
Optimization
SMEDDS
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Sat, 04 Jun 2016, 12:25:26 EST by Nirmal Marasini on behalf of Learning and Research Services (UQ Library)