Physicochemical characterization and in vivo evaluation of solid self-nanoemulsifying drug delivery system for oral administration of docetaxel

Quan, Qizhe, Kim, Dong-Wuk, Marasini, Nirmal, Kim, Dae Hwan, Kim, Jin Ki, Kim, Jong Oh, Yong, Chul Soon and Choi, Han-Gon (2013) Physicochemical characterization and in vivo evaluation of solid self-nanoemulsifying drug delivery system for oral administration of docetaxel. Journal of Microencapsulation, 30 4: 307-314. doi:10.3109/02652048.2012.726280


Author Quan, Qizhe
Kim, Dong-Wuk
Marasini, Nirmal
Kim, Dae Hwan
Kim, Jin Ki
Kim, Jong Oh
Yong, Chul Soon
Choi, Han-Gon
Title Physicochemical characterization and in vivo evaluation of solid self-nanoemulsifying drug delivery system for oral administration of docetaxel
Journal name Journal of Microencapsulation   Check publisher's open access policy
ISSN 0265-2048
1464-5246
Publication date 2013
Sub-type Article (original research)
DOI 10.3109/02652048.2012.726280
Open Access Status Not Open Access
Volume 30
Issue 4
Start page 307
End page 314
Total pages 8
Place of publication Abingdon, Oxfordshire United Kingdom
Publisher Taylor & Francis
Language eng
Abstract To formulate a self-nanoemulsifying drug delivery system (SNEDDS) for the oral administration of docetaxel as an alternative to commercial docetaxel-loaded injectable products, it was prepared by spray-drying an aqueous solution containing liquid SNEDDS and colloidal silica. Its physicochemical properties and oral bioavailability were investigated compared to a clear docetaxel solution administered intravenously or orally to rats. In the docetaxel-loaded solid SNEDDS prepared with colloidal silica, the liquid SNEDDS composed of Capryol 90, Cremophore EL and Transcutol HP (45/35/20, volume ratio) was absorbed inside the pores of carriers, and docetaxel was present in a changed amorphous state. The solid SNEDDS with 3.3% (w/v) docetaxel produced nanoemulsions, and showed about 12.5% absolute bioavailability in rats. Thus, this solid SNEDDS may be a potential candidate for oral pharmaceutical product with improved oral bioavailability of docetaxel.
Keyword Docetaxel
Solid self-nanoemulsifying drug delivery system
Absolute bioavailability
Capryol 90
Cremophore EL
Transcutol HP
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Sat, 04 Jun 2016, 12:18:23 EST by Nirmal Marasini on behalf of School of Chemistry & Molecular Biosciences