Effects of silicone-based gels containing allantoin, dexpanthenol and heparin on hypertrophic scarring in the rabbit ear model

Kim, Gun Gook, Ku, Sae Kwang, Lee, Dong Won, Marasini, Nirmal, Pradhan, Roshan, Son, Mi-Won, Jun, Joon Ho, Jang, Sun Woo, Jin, Sung Giu, Kang, Min Kyung, Yong, Chul Soon, Choi, Han-Gon and Kim, Jong Oh (2012) Effects of silicone-based gels containing allantoin, dexpanthenol and heparin on hypertrophic scarring in the rabbit ear model. Drug Development Research, 73 3: 146-153. doi:10.1002/ddr.21004


Author Kim, Gun Gook
Ku, Sae Kwang
Lee, Dong Won
Marasini, Nirmal
Pradhan, Roshan
Son, Mi-Won
Jun, Joon Ho
Jang, Sun Woo
Jin, Sung Giu
Kang, Min Kyung
Yong, Chul Soon
Choi, Han-Gon
Kim, Jong Oh
Title Effects of silicone-based gels containing allantoin, dexpanthenol and heparin on hypertrophic scarring in the rabbit ear model
Journal name Drug Development Research   Check publisher's open access policy
ISSN 0272-4391
1098-2299
Publication date 2012-05
Year available 2012
Sub-type Article (original research)
DOI 10.1002/ddr.21004
Open Access Status Not Open Access
Volume 73
Issue 3
Start page 146
End page 153
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Silicone-based formulations are extensively used for the management of hypertrophic scars. Although the exact mechanism of action is still unknown, it has been postulated that some occlusion and hydration of the stratum corneum with subsequent cytokine-mediated signaling from keratinocytes to dermal fibroblasts is involved in its antiscarring effects. In this study, the effectiveness of silicone-based gels containing allantoin, dexpanthenol, and heparin was evaluated for improving the healing of hypertrophic scars. It was found that silicone-based gels showed remarkable improvements in hypertrophic scar healing and low amounts of skin pigmentation in the rabbit ear model compared with the nontreated control or base alone. Furthermore, the histopathological and histomorphometrical profiles of three different formulations containing 1%, 5%, and 20% silicone contents exhibited marked or significant decreases in the scar elevation index, anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization, and fibroblasts compared with nontreated control hypertrophic scars. Therefore, these results indicate that silicone-based gels containing heparin, allantoin, and dexpanthenol could be promising formulations for the healing of hypertrophic scars.
Keyword Allantoin
Dexpanthenol
Gel
Heparin
Hypertrophic scar
Silicone
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Sat, 04 Jun 2016, 12:15:37 EST by Nirmal Marasini on behalf of Learning and Research Services (UQ Library)