Enhancement of oral bioavailability of fenofibrate by solid self-microemulsifying drug delivery systems

Kim, Gun Gook, Poudel, Bijay K., Marasini, Nirmal, Lee, Dong Won, Tran Tuan Hiep, Yang, Kwan Yeol, Kim, Jong Oh, Yong, Chul Soon and Choi, Han-Gon (2013) Enhancement of oral bioavailability of fenofibrate by solid self-microemulsifying drug delivery systems. Drug Development and Industrial Pharmacy, 39 9: 1431-1438. doi:10.3109/03639045.2012.719903


Author Kim, Gun Gook
Poudel, Bijay K.
Marasini, Nirmal
Lee, Dong Won
Tran Tuan Hiep
Yang, Kwan Yeol
Kim, Jong Oh
Yong, Chul Soon
Choi, Han-Gon
Title Enhancement of oral bioavailability of fenofibrate by solid self-microemulsifying drug delivery systems
Journal name Drug Development and Industrial Pharmacy   Check publisher's open access policy
ISSN 0363-9045
1520-5762
Publication date 2013
Sub-type Article (original research)
DOI 10.3109/03639045.2012.719903
Open Access Status Not Open Access
Volume 39
Issue 9
Start page 1431
End page 1438
Total pages 8
Place of publication Philadelphia, PA United States
Publisher Taylor & Francis
Language eng
Abstract A solid form of self-microemulsifying drug delivery system (Solid SMEDDS) was developed by spray-drying with dextran as the inert solid carrier, to improve the oral bioavailability of a poorly water-soluble drug, fenofibrate. The optimized liquid SMEDDS, composed of Labrafil M 1944 CS/Labrasol/Capryol PGMC (15/75/10%v/v) with 10% w/v fenofibrate gave a z-average diameter of around 240nm. There was no significant difference in the mean droplet size and size distribution of the emulsions obtained from the liquid and solid forms of SMEDDS. Solid state characterizations of solid SMEDDS showed that the crystal state of fenofibrate in solid SMEDDS was converted from crystalline to amorphous form. Solid SMEDDS had significantly higher dissolution rates than the drug powder, due to its fast self-emulsification in the dissolution media. Furthermore, the AUC value of solid SMEDDS was twofold greater than that of the powder, indicating this formulation greatly improved the oral bioavailability of drug in rats. Thus, these results suggest that solid SMEDDS could be used as an effective oral solid dosage form to improve dissolution and oral bioavailability of fenofibrate.
Keyword SMEDDS
Bioavailability
Solubility
Spray drying
Fenofibrate
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 04 Jun 2016, 12:13:26 EST by Nirmal Marasini on behalf of School of Chemistry & Molecular Biosciences