Development and optimization of self-nanoemulsifying drug delivery system with enhanced bioavailability by Box-Behnken design and desirability function

Marasini, Nirmal, Yan, Yi Dong, Poudel, Bijay Kumar, Choi, Han-Gon, Yong, Chul Soon and Kim, Jong Oh (2012) Development and optimization of self-nanoemulsifying drug delivery system with enhanced bioavailability by Box-Behnken design and desirability function. Journal of Pharmaceutical Sciences, 101 12: 4584-4596. doi:10.1002/jps.23333


Author Marasini, Nirmal
Yan, Yi Dong
Poudel, Bijay Kumar
Choi, Han-Gon
Yong, Chul Soon
Kim, Jong Oh
Title Development and optimization of self-nanoemulsifying drug delivery system with enhanced bioavailability by Box-Behnken design and desirability function
Journal name Journal of Pharmaceutical Sciences   Check publisher's open access policy
ISSN 0022-3549
1520-6017
Publication date 2012-12
Year available 2012
Sub-type Article (original research)
DOI 10.1002/jps.23333
Open Access Status Not Open Access
Volume 101
Issue 12
Start page 4584
End page 4596
Total pages 13
Place of publication New York, NY, United States
Publisher Elsevier
Language eng
Formatted abstract
The aim of our study was to characterize and optimize a self-nanoemulsifying drug delivery system (SNEDDS) formulation by a three-factor, three-level Box-Behnken design (BBD) combined with a desirability function. The independent factors were the amounts of Capryol PGMC (X1), Tween 20 (X2), and Transcutol HP (X3). The dependent variables were droplet size (Y1), equilibrium solubility (Y2), and cumulative percentage of drug released in 15 min (Y3) from the SNEDDS formulation. The responses were fitted to a second-order quadratic model and statistical validation of the fitted models was carried out by analysis of variance. Various response surface graphs and contour plots were constructed to understand the effects of different factor level combinations on the responses. The optimized SNEDDS formulation consisting of Capryol PGMC-Tween 20-Transcutol HP at proportions of 5:58.4:40 (w/w) was prepared and a comparison of the predicted values and experimental values was found to be in close agreement. Furthermore, an in vivo pharmacokinetic study of the optimized SNEDDS formulation showed a 2.2-fold increase in relative oral bioavailability compared with that of the suspension. In conclusion, the BBD demonstrated its effectiveness in optimizing the SNEDDS formulation and in understanding the effects of formulation variables on the performance of SNEDDS.
Keyword Bioavailability
Biopharmaceutics Classification System (BCS)
Box-Behnken design
Desirability function
Dissolution
Flurbiprofen
Optimization
Particle size
SNEDDS
Solubility
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Sat, 04 Jun 2016, 11:52:47 EST by Nirmal Marasini on behalf of Learning and Research Services (UQ Library)