Methicillin-resistant Staphylococcus aureus acquisition in healthcare workers with cystic fibrosis: a retrospective cross-sectional study

Wood, Michelle E., Sherrard, Laura J., Ramsay, Kay A., Yerkovich, Stephanie T., Reid, David W., Kidd, Timothy J. and Bell, Scott C. (2016) Methicillin-resistant Staphylococcus aureus acquisition in healthcare workers with cystic fibrosis: a retrospective cross-sectional study. BMC Pulmonary Medicine, 16 78: 1-7. doi:10.1186/s12890-016-0243-z


Author Wood, Michelle E.
Sherrard, Laura J.
Ramsay, Kay A.
Yerkovich, Stephanie T.
Reid, David W.
Kidd, Timothy J.
Bell, Scott C.
Title Methicillin-resistant Staphylococcus aureus acquisition in healthcare workers with cystic fibrosis: a retrospective cross-sectional study
Formatted title
Methicillin-resistant Staphylococcus aureus acquisition in healthcare workers with cystic fibrosis: a retrospective cross-sectional study
Journal name BMC Pulmonary Medicine   Check publisher's open access policy
ISSN 1471-2466
Publication date 2016-05-11
Year available 2016
Sub-type Article (original research)
DOI 10.1186/s12890-016-0243-z
Open Access Status DOI
Volume 16
Issue 78
Start page 1
End page 7
Total pages 7
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2017
Language eng
Formatted abstract
Background
People with cystic fibrosis (CF) may work in healthcare settings risking nosocomial pathogen acquisition. The aim of this study was to determine the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection in adult healthcare workers with CF (HCWcf).

Methods
Data was collected in this observational study on MRSA acquisition from 405 CF patients attending an adult CF centre in Australia between 2001–2012. Demographic and clinical characteristics were compared between HCWcf and non-HCWcf. A sub-analysis was subsequently performed to compare demographic and clinical characteristics between those patients (HCWcf versus non-HCWcf) that acquired MRSA. We also investigated rates of chronic MRSA infection and the outcome of eradication treatment in HCWcf.

Results
A higher proportion of HCWcf acquired MRSA [n = 10/21] compared to non-HCWcf [n = 40/255] (P <0.001). The odds of MRSA acquisition were 8.4 (95 % CI, 3.0 – 23.4) times greater in HCWcf than non-HCWcf. HCWcf with MRSA were older (P = 0.02) and had better lung function (P = 0.009), yet hospitalisation rates were similar compared to non-HCWcf with MRSA. Chronic MRSA infection developed in 36/50 CF patients (HCWcf, n = 6; non-HCWcf, n = 30), with eradication therapy achieved in 5/6 (83 %) HCWcf.

Conclusions
The rate of MRSA incidence was highest in HCWcf and the workplace is a possible source of acquisition. Vocational guidance should include the potential for MRSA acquisition for CF patients considering healthcare professions.
Keyword MRSA
Cystic fibrosis
Employment
Incidence
Nosocomial infection
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Fri, 03 Jun 2016, 10:22:29 EST by Mrs Louise Nimwegen on behalf of School of Medicine