Cytokines in the oral mucosa of mice infected with Candida albicans

Farah, C. S., Gotjamanos, T., Seymour, G. J. and Ashman, R. B. (2002) Cytokines in the oral mucosa of mice infected with Candida albicans. Oral Microbiology And Immunology, 17 6: 375-378. doi:10.1034/j.1399-302X.2002.170607.x

Author Farah, C. S.
Gotjamanos, T.
Seymour, G. J.
Ashman, R. B.
Title Cytokines in the oral mucosa of mice infected with Candida albicans
Journal name Oral Microbiology And Immunology   Check publisher's open access policy
ISSN 0902-0055
Publication date 2002-12
Sub-type Article (original research)
DOI 10.1034/j.1399-302X.2002.170607.x
Volume 17
Issue 6
Start page 375
End page 378
Total pages 4
Place of publication Copenhagen
Publisher Blackwell Science
Language eng
Abstract Oropharyngeal candidiasis is associated with defects in cell-mediated immunity, and is commonly seen in immunocompromised patients. We have previously shown that T-cell-deficient BALB/c nude (nu/nu) mice are extremely susceptible to oropharyngeal candidiasis, and that recovery from a chronic infection is dependent on CD4 T lymphocytes. In this study we describe the local tissue cytokine profile in lymphocyte-reconstituted immunodeficient mice and their euthymic counterparts. Mice were infected orally with 10(8) cells of the yeast Candida albicans , and oral tissues sampled on days 0, 4, 8, and 14. Nude mice were reconstituted with 3 x 10(7) naive lymphocytes following oral inoculation. Interleukin (IL)-6, interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha were identified in the oral tissues of infected euthymic mice recovering from oral infection, as well as naive controls. TNF-alpha was identified in nude oral tissue on days 4 and 8, but only after lymphocyte reconstitution. No IL-2, IL-4 or IL-10 was detected in either euthymic or athymic mice at any time-point throughout the experiment. This study confirms the functional activity of T lymphocytes in reconstituted nude mice, and suggests that TNF-alpha may be an important mediator in the recovery from oropharyngeal candidiasis.
Keyword Dentistry, Oral Surgery & Medicine
Oral Candidiasis
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Dentistry Publications
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Created: Mon, 13 Aug 2007, 13:19:45 EST