Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events

Hoen, Anne Gatewood, Margos, Gabriele, Bent, Stephen J., Diuk-Wasser, Maria A., Barbour, Alan, Kurtenbach, Klaus and Fish, Durland (2009) Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events. Proceedings of the National Academy of Sciences, 106 35: 15013-15018. doi:10.1073/pnas.0903810106


Author Hoen, Anne Gatewood
Margos, Gabriele
Bent, Stephen J.
Diuk-Wasser, Maria A.
Barbour, Alan
Kurtenbach, Klaus
Fish, Durland
Title Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events
Formatted title
Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events
Journal name Proceedings of the National Academy of Sciences   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2009-09-01
Sub-type Article (original research)
DOI 10.1073/pnas.0903810106
Open Access Status Not yet assessed
Volume 106
Issue 35
Start page 15013
End page 15018
Total pages 6
Place of publication Washington, DC, United States
Publisher National Academy of Sciences
Language eng
Formatted abstract
Since its first description in coastal Connecticut in 1976, both the incidence of Lyme disease and the geographic extent of endemic areas in the US have increased dramatically. The rapid expansion of Lyme disease into its current distribution in the eastern half of the US has been due to the range expansion of the tick vector, Ixodes scapularis, upon which the causative agent, Borrelia burgdorferi is dependent for transmission to humans. In this study, we examined the phylogeographic population structure of B. burgdorferi throughout the range of I. scapularis-borne Lyme disease using multilocus sequence typing based on bacterial housekeeping genes. We show that B. burgdorferi populations from the Northeast and Midwest are genetically distinct, but phylogenetically related. Our findings provide strong evidence of prehistoric population size expansion and east-to-west radiation of descendent clones from founding sequence types in the Northeast. Estimates of the time scale of divergence of northeastern and midwestern populations suggest that B. burgdorferi was present in these regions of North America many thousands of years before European settlements. We conclude that B. burgdorferi populations have recently reemerged independently out of separate relict foci, where they have persisted since precolonial times.
Keyword Geography
Multilocus sequence typing
Phylogeny
Ticks
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 70 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 76 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 31 May 2016, 21:04:37 EST by Stephen Bent on behalf of Learning and Research Services (UQ Library)