Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice

Guo, Hong, Jin, Daozhong, Zhang, Yuanyuan, Wright, Wendy, Bazuine, Merlijn, Brockman, David A., Bernlohr, David A. and Chen, Xiaoli (2010) Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice. Diabetes, 59 6: 1376-1385. doi:10.2337/db09-1735


Author Guo, Hong
Jin, Daozhong
Zhang, Yuanyuan
Wright, Wendy
Bazuine, Merlijn
Brockman, David A.
Bernlohr, David A.
Chen, Xiaoli
Title Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice
Journal name Diabetes   Check publisher's open access policy
ISSN 0012-1797
1939-327X
Publication date 2010-06-01
Sub-type Article (original research)
DOI 10.2337/db09-1735
Open Access Status Not yet assessed
Volume 59
Issue 6
Start page 1376
End page 1385
Total pages 10
Place of publication Alexandria, VA, United States
Publisher American Diabetes Association
Language eng
Formatted abstract
Objective: Lipocalin (LCN) 2 belongs to the lipocalin subfamily of low-molecular mass-secreted proteins that bind small hydrophobic molecules. LCN2 has been recently characterized as an adipose-derived cytokine, and its expression is upregulated in adipose tissue in genetically obese rodents. The objective of this study was to investigate the role of LCN2 in diet-induced insulin resistance and metabolic homeostasis in vivo.

Research Design and Methods: Systemic insulin sensitivity, adaptive thermogenesis, and serum metabolic and lipid profile were assessed in LCN2-deficient mice fed a high-fat diet (HFD) or regular chow diet.

Results: The molecular disruption of LCN2 in mice resulted in significantly potentiated diet-induced obesity, dyslipidemia, fatty liver disease, and insulin resistance. LCN2-/- mice exhibit impaired adaptive thermogenesis and cold intolerance. Gene expression patterns in white and brown adipose tissue, liver, and muscle indicate that LCN2-/- mice have increased hepatic gluconeogenesis, decreased mitochondrial oxidative capacity, impaired lipid metabolism, and increased inflammatory state under the HFD condition.

Conclusions: LCN2 has a novel role in adaptive thermoregulation and diet-induced insulin resistance.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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