Periostin levels and eosinophilic inflammation in poorly-controlled asthma

Simpson, Jodie L., Yang, Ian A., Upham, John W., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Jenkins, Christine, Peters, Matthew J., Jia, Guiquan, Holweg, Cecile T. J. and Gibson, Peter G. (2016) Periostin levels and eosinophilic inflammation in poorly-controlled asthma. BMC Pulmonary Medicine, 16 67.1-67.7. doi:10.1186/s12890-016-0230-4


Author Simpson, Jodie L.
Yang, Ian A.
Upham, John W.
Reynolds, Paul N.
Hodge, Sandra
James, Alan L.
Jenkins, Christine
Peters, Matthew J.
Jia, Guiquan
Holweg, Cecile T. J.
Gibson, Peter G.
Title Periostin levels and eosinophilic inflammation in poorly-controlled asthma
Journal name BMC Pulmonary Medicine   Check publisher's open access policy
ISSN 1471-2466
Publication date 2016-04-30
Year available 2016
Sub-type Article (original research)
DOI 10.1186/s12890-016-0230-4
Open Access Status DOI
Volume 16
Start page 67.1
End page 67.7
Total pages 7
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2017
Language eng
Formatted abstract
Background: Periostin levels are associated with airway eosinophilia and are suppressed by corticosteroid
treatment in asthma. This study sought to determine the relationship between serum and sputum periostin,
airway inflammatory phenotype and asthma control.

Methods: Adults with poorly-controlled asthma (n = 83) underwent a clinical assessment, sputum induction and
blood sampling. Dispersed sputum was used for a differential cell count and periostin assessment (ELISA). Serum
periostin was determined by the Elecsys® immunoassay.

Results: Periostin levels were significantly higher in serum (median (IQR) of 51.6 (41.8, 62.6) ng/mL) than in sputum
(1.1 (0.5, 2.0) ng/mL) (p < 0.001). Serum and sputum periostin were significantly higher in patients with eosinophilic
asthma (n = 37) compared with non-eosinophilic asthma. Both serum and sputum periostin levels were significantly
associated with proportion of sputum eosinophils (r = 0.422, p < 0.001 and r = 0.364, p = 0.005 respectively) but
were not associated with asthma control. In receiver operator characteristic curve analysis, the area under the
curve (AUC) for serum periostin (n = 83) was 0.679, p = 0.007. Peripheral blood eosinophils assessed in 67 matched
samples, had a numerically greater AUC of 0.820 compared with serum periostin, p = 0.086 for the detection of
eosinophilic asthma.

Conclusion: In poorly-controlled asthma, sputum and serum periostin levels are significantly related to sputum
eosinophil proportions while their ability to predict the presence of eosinophilic asthma is modest.
Keyword Periostin
Eosinophilic asthma
Non-eosinophillic asthma
Phenotype
Inflammation
Airway Inflammation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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