Free light chain testing for the diagnosis, monitoring and prognostication of AL amyloidosis

Mollee, Peter and Merlini, Giampaolo (2016) Free light chain testing for the diagnosis, monitoring and prognostication of AL amyloidosis. Clinical Chemistry and Laboratory Medicine, 54 6: 921-927. doi:10.1515/cclm-2015-0938


Author Mollee, Peter
Merlini, Giampaolo
Title Free light chain testing for the diagnosis, monitoring and prognostication of AL amyloidosis
Journal name Clinical Chemistry and Laboratory Medicine   Check publisher's open access policy
ISSN 1434-6621
1437-4331
Publication date 2016-06
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1515/cclm-2015-0938
Open Access Status Not Open Access
Volume 54
Issue 6
Start page 921
End page 927
Total pages 7
Place of publication Berlin, Germany
Publisher Walter de Gruyter GmbH
Collection year 2017
Language eng
Abstract The disease causing agent in systemic AL amyloidosis is a monoclonal immunoglobulin free light chain, or fragments thereof, circulating in the blood. It is not surprising, therefore, that measurement of serum free light chains plays a central role in the management of this disorder. In this paper, we review the utility of the serum free light chain assay in the investigation, prognostication and monitoring of AL amyloidosis. Data on the two currently available commercial assays is compared and some practical applications of the assay's use are presented. While there are limitations, it is clear that the availability of the free light chain assay in the laboratory is a major advance and plays an essential role in the management of patients with AL amyloidosis.
Keyword AL amyloidosis
Free light chains
Monitoring
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
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