Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

Collins, Nicholas, Jiang, Xiaodong, Zaid, Ali, Macleod, Bethany L., Li, Jane, Park, Chang Ook, Haque, Ashraful, Bedoui, Sammy, Heath, William R., Mueller, Scott N., Kupper, Thomas S., Gebhardt, Thomas and Carbone, Francis R. (2016) Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation. Nature Communications, 7 . doi:10.1038/ncomms11514


Author Collins, Nicholas
Jiang, Xiaodong
Zaid, Ali
Macleod, Bethany L.
Li, Jane
Park, Chang Ook
Haque, Ashraful
Bedoui, Sammy
Heath, William R.
Mueller, Scott N.
Kupper, Thomas S.
Gebhardt, Thomas
Carbone, Francis R.
Title Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
Formatted title
Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2016-05-10
Year available 2016
Sub-type Article (original research)
DOI 10.1038/ncomms11514
Open Access Status DOI
Volume 7
Total pages 13
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2017
Language eng
Formatted abstract
Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that memory CD4T cells in mouse skin are in equilibrium with the circulation at steady state. These cells are dispersed throughout the inter-follicular regions of the dermis and form clusters with antigen presenting cells around hair follicles. After infection or administration of a contact sensitizing agent, there is a sustained increase in skin CD4+ T-cell content, which is confined to the clusters, with a concomitant CCL5-dependent increase in CD4+ T-cell recruitment. Skin CCL5 is derived from CD11b+ cells and CD8+ T cells, with the elimination of the latter decreasing CD4+ T-cell numbers. These results reveal a complex pattern of tissue-retention and equilibration for CD4+ memory T cells in skin, which is altered by infection and inflammation history.
Keyword Skin CD4+ memory T cells
Recirculation
Specific immunity against infection
Immunology
T cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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