Modifiers of epigenetic reprogramming show paternal effects in the mouse

Chong, Suyinn, Vickaryous, Nicola, Ashe, Alyson, Zamudio, Natasha, Youngson, Neil, Hemley, Sarah, Stopka, Tomas, Skoultchi, Arthur, Matthews, Jacqui, Scott, Hamish S., de Kretser, David, O'Bryan, Moira, Blewitt, Marnie and Whitelaw, Emma (2007) Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nature Genetics, 39 5: 614-622. doi:10.1038/ng2031

Author Chong, Suyinn
Vickaryous, Nicola
Ashe, Alyson
Zamudio, Natasha
Youngson, Neil
Hemley, Sarah
Stopka, Tomas
Skoultchi, Arthur
Matthews, Jacqui
Scott, Hamish S.
de Kretser, David
O'Bryan, Moira
Blewitt, Marnie
Whitelaw, Emma
Title Modifiers of epigenetic reprogramming show paternal effects in the mouse
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2007
Sub-type Article (original research)
DOI 10.1038/ng2031
Volume 39
Issue 5
Start page 614
End page 622
Total pages 9
Language eng
Subject 2716 Genetics (clinical)
1311 Genetics
Abstract There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and in the early developing embryo. One corollary to this is that disrupting the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occur following paternal inheritance in the mouse. We detected changes to transcription and chromosome ploidy in adult animals. Paternal effects of this type have not been reported previously in mammals and suggest that the untransmitted genotype of male parents can influence the phenotype of their offspring.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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