White matter hyperintensities are under strong genetic influence

Sachdev, Perminder S., Thalamuthu, Anbupalam, Mather, Karen A., Ames, David, Wright, Margaret J. and Wen, Wei (2016) White matter hyperintensities are under strong genetic influence. Stroke, 47 6: 1422-U124. doi:10.1161/STROKEAHA.116.012532


Author Sachdev, Perminder S.
Thalamuthu, Anbupalam
Mather, Karen A.
Ames, David
Wright, Margaret J.
Wen, Wei
Title White matter hyperintensities are under strong genetic influence
Journal name Stroke   Check publisher's open access policy
ISSN 1524-4628
0039-2499
Publication date 2016-05-10
Sub-type Article (original research)
DOI 10.1161/STROKEAHA.116.012532
Volume 47
Issue 6
Start page 1422
End page U124
Total pages 20
Place of publication Philadelphia, United States
Publisher Lippincott Williams and Wilkins
Collection year 2017
Language eng
Formatted abstract
Background and Purpose—The genetic basis of white matter hyperintensities (WMH) is still unknown. This study examines the heritability of WMH in both sexes and in different brain regions, and the influence of age.

Methods—Participants from the Older Australian Twins Study were recruited (n=320; 92 monozygotic and 68 dizygotic pairs) who volunteered for magnetic resonance imaging scans and medical assessments. Heritability, that is, the ratio of the additive genetic variance to the total phenotypic variance, was estimated using the twin design.

Results—Heritability was high for total WMH volume (0.76), and for periventricular WMH (0.64) and deep WMH (0.77), and varied from 0.18 for the cerebellum to 0.76 for the occipital lobe. The genetic correlation between deep and periventricular WMH regions was 0.85, with one additive genetics factor accounting for most of the shared variance. Heritability was consistently higher in women in the cerebral regions. Heritability in deep but not periventricular WMH declined with age, in particular after the age of 75.

Conclusions—WMH have a strong genetic influence but this is not uniform through the brain, being higher for deep than periventricular WMH and in the cerebral regions. The genetic influence is higher in women, and there is an age-related decline, most markedly for deep WMH. The data suggest some heterogeneity in the pathogenesis of WMH for different brain regions and for men and women.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Created: Fri, 27 May 2016, 11:46:33 EST by Susan Day on behalf of Learning and Research Services (UQ Library)