MECHANISMS IN ENDOCRINOLOGY: brown adipose tissue in humans: regulation and metabolic significance

Thuzar, Moe and Ho, Ken K. Y. (2016) MECHANISMS IN ENDOCRINOLOGY: brown adipose tissue in humans: regulation and metabolic significance. European Journal of Endocrinology, 175 1: R11-R25. doi:10.1530/EJE-15-1217


Author Thuzar, Moe
Ho, Ken K. Y.
Title MECHANISMS IN ENDOCRINOLOGY: brown adipose tissue in humans: regulation and metabolic significance
Journal name European Journal of Endocrinology   Check publisher's open access policy
ISSN 0804-4643
1479-683X
Publication date 2016-07-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1530/EJE-15-1217
Open Access Status Not Open Access
Volume 175
Issue 1
Start page R11
End page R25
Total pages 15
Place of publication Bristol, United Kingdom
Publisher BioScientifica
Collection year 2017
Language eng
Abstract The recent discovery that functional brown adipose tissue (BAT) persists in adult humans has enkindled a renaissance in metabolic research, with a view of harnessing its thermogenic capacity to combat obesity. This review focuses on the advances in the regulation and the metabolic significance of BAT in humans. BAT activity in humans is stimulated by cold exposure and by several factors such as diet and metabolic hormones. BAT function is regulated at two levels: an acute process involving the stimulation of the intrinsic thermogenic activity of brown adipocytes and a chronic process of growth involving the proliferation of pre-existing brown adipocytes or differentiation to brown adipocytes of adipocytes from specific white adipose tissue depots. BAT activity is reduced in the obese, and its stimulation by cold exposure increases insulin sensitivity and reduces body fat. These observations provide strong evidence that BAT plays a significant role in energy balance in humans and has the potential to be harnessed as a therapeutic target for the management of obesity.
Keyword Brown adipose tissue
Regulation
Humans
Metabolism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
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Created: Wed, 25 May 2016, 11:46:40 EST by Moe Thuzar on behalf of Medicine - Princess Alexandra Hospital