EphA3 biology and cancer

Janes, Peter W., Slape, Christopher I., Farnsworth, Rae H., Atapattu, Lakmali, Scott, Andrew M. and Vail, Mary E. (2014) EphA3 biology and cancer. Growth Factors, 32 6: 176-189. doi:10.3109/08977194.2014.982276

Author Janes, Peter W.
Slape, Christopher I.
Farnsworth, Rae H.
Atapattu, Lakmali
Scott, Andrew M.
Vail, Mary E.
Title EphA3 biology and cancer
Journal name Growth Factors   Check publisher's open access policy
ISSN 1029-2292
Publication date 2014-12-01
Year available 2014
Sub-type Article (original research)
DOI 10.3109/08977194.2014.982276
Open Access Status Not yet assessed
Volume 32
Issue 6
Start page 176
End page 189
Total pages 14
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Language eng
Formatted abstract
Eph receptor tyrosine kinases control cell-cell interactions during normal and oncogenic development, and are implicated in a range of processes including angiogenesis, stem cell maintenance and metastasis. They are thus of great interest as targets for cancer therapy. EphA3, originally isolated from leukemic and melanoma cells, is presently one of the most promising therapeutic targets, with multiple tumor-promoting roles in a variety of cancer types. This review focuses on EphA3, its functions in controlling cellular behavior, both in normal and pathological development, and most particularly in cancer.
Keyword Cancer
Cell-cell interaction
Eph receptor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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