Fluorinated POSS-star polymers for 19F MRI

Wang, Kewei, Peng, Hui, Thurecht, Kristofer J. and Whittaker, Andrew K. (2016) Fluorinated POSS-star polymers for 19F MRI. Macromolecular Chemistry and Physics, . doi:10.1002/macp.201600084


Author Wang, Kewei
Peng, Hui
Thurecht, Kristofer J.
Whittaker, Andrew K.
Title Fluorinated POSS-star polymers for 19F MRI
Formatted title
Fluorinated POSS-star polymers for 19F MRI
Journal name Macromolecular Chemistry and Physics   Check publisher's open access policy
ISSN 1521-3935
1022-1352
Publication date 2016-05-06
Year available 2016
Sub-type Article (original research)
DOI 10.1002/macp.201600084
Open Access Status Not Open Access
Total pages 13
Place of publication Weinheim, Germany
Publisher Wiley-VCH Verlag
Collection year 2017
Language eng
Formatted abstract
Star polymers with a polyhedral oligomeric silsesquioxanes (POSS) core and eight partly fluorinated arms have been synthesized by reversible addition-fragmentation chain transfer polymerization. A macroCTA having eight chain transfer agent (CTA) molecules attached to a POSS core is prepared and used for the synthesis of star polymers by the R-group approach. The arms are composed of statistical copolymers of 2,2,2-trifluoroethyl acrylate and poly(ethylene glycol) methyl ether acrylate. The polymerization kinetics are studied, and yield of star polymer is optimized. Star polymers having different arm lengths are prepared and characterized. The star polymers exhibit a single 19F resonance in 19F nuclear magnetic resonance spectra in aqueous solution, and the T2 relaxation time increases with arm length. The relaxation properties and the fluorine content are consistent with these polymers being effective 19F magnetic resonance imaging (MRI) agents. This work indicates that these POSS-star polymers have potential as theranostic agents for 19F MRI and drug delivery.
Keyword 19F magnetic resonance imaging (MRI)
Polyhedral oligomeric silsesquioxanes (POSS)
Reversible addition-fragmentation chain transfer (RAFT) polymerization
Star polymers
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
Centre for Advanced Imaging Publications
 
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