Comparative measurement and quantitative risk assessment of alcohol consumption through wastewater-based epidemiology: an international study in 20 cities

Ryu, Yeonsuk, Barcelo, Damià, Barron, Leon P., Bijlsma, Lubertus, Castiglioni, Sara, de Voogt, Pim, Emke, Erik, Hernandez, Félix, Lai, Foon Yin, Lopes, Alvaro, de Alda, Miren López, Mastroianni, Nicola, Munro, Kelly, O'Brien, Jake, Ort, Christoph, Plosz, Benedek G., Reid, Malcolm J., Yargeau, Viviane and Thomas, Kevin V. (2016) Comparative measurement and quantitative risk assessment of alcohol consumption through wastewater-based epidemiology: an international study in 20 cities. Science of the Total Environment, 565 977-983. doi:10.1016/j.scitotenv.2016.04.138


Author Ryu, Yeonsuk
Barcelo, Damià
Barron, Leon P.
Bijlsma, Lubertus
Castiglioni, Sara
de Voogt, Pim
Emke, Erik
Hernandez, Félix
Lai, Foon Yin
Lopes, Alvaro
de Alda, Miren López
Mastroianni, Nicola
Munro, Kelly
O'Brien, Jake
Ort, Christoph
Plosz, Benedek G.
Reid, Malcolm J.
Yargeau, Viviane
Thomas, Kevin V.
Title Comparative measurement and quantitative risk assessment of alcohol consumption through wastewater-based epidemiology: an international study in 20 cities
Journal name Science of the Total Environment   Check publisher's open access policy
ISSN 1879-1026
0048-9697
Publication date 2016-09-15
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.scitotenv.2016.04.138
Open Access Status DOI
Volume 565
Start page 977
End page 983
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2017
Language eng
Abstract Quantitative measurement of drug consumption biomarkers in wastewater can provide objective information on community drug use patterns and trends. This study presents the measurement of alcohol consumption in 20 cities across 11 countries through the use of wastewater-based epidemiology (WBE), and reports the application of these data for the risk assessment of alcohol on a population scale using the margin of exposure (MOE) approach. Raw 24-h composite wastewater samples were collected over a one-week period from 20 cities following a common protocol. For each sample a specific and stable alcohol consumption biomarker, ethyl sulfate (EtS) was determined by liquid chromatography coupled to tandem mass spectrometry. The EtS concentrations were used for estimation of per capita alcohol consumption in each city, which was further compared with international reports and applied for risk assessment by MOE. The average per capita consumption in 20 cities ranged between 6.4 and 44.3. L/day/1000 inhabitants. An increase in alcohol consumption during the weekend occurred in all cities, however the level of this increase was found to differ. In contrast to conventional data (sales statistics and interviews), WBE revealed geographical differences in the level and pattern of actual alcohol consumption at an inter-city level. All the sampled cities were in the "high risk" category (MOE. <. 10) and the average MOE for the whole population studied was 2.5. These results allowed direct comparisons of alcohol consumption levels, patterns and risks among the cities. This study shows that WBE can provide timely and complementary information on alcohol use and alcohol associated risks in terms of exposure at the community level.
Keyword Alcohol
Biomarker analysis
Drug epidemiology
Ethyl sulfate
Margin of exposure
Wastewater
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
National Research Centre for Environmental Toxicology Publications
 
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