Facilitating a culture of responsible and effective sharing of cancer genome data

Siu, Lillian L., Lawler, Mark, Haussler, David, Knoppers, Bartha Maria, Lewin, Jeremy, Vis, Daniel J., Liao, Rachel G., Andre, Fabrice, Banks, Ian, Barrett, J. Carl, Caldas, Carlos, Camargo, Anamaria Aranha, Fitzgerald, Rebecca C., Mao, Mao, Mattison, John E., Pao, William, Sellers, William R., Sullivan, Patrick, Teh, Bin Tean, Ward, Robyn L., Zenklusen, Jean Claude, Sawyers, Charles L. and Voest, Emile E. (2016) Facilitating a culture of responsible and effective sharing of cancer genome data. Nature Medicine, 22 5: 464-471. doi:10.1038/nm.4089


Author Siu, Lillian L.
Lawler, Mark
Haussler, David
Knoppers, Bartha Maria
Lewin, Jeremy
Vis, Daniel J.
Liao, Rachel G.
Andre, Fabrice
Banks, Ian
Barrett, J. Carl
Caldas, Carlos
Camargo, Anamaria Aranha
Fitzgerald, Rebecca C.
Mao, Mao
Mattison, John E.
Pao, William
Sellers, William R.
Sullivan, Patrick
Teh, Bin Tean
Ward, Robyn L.
Zenklusen, Jean Claude
Sawyers, Charles L.
Voest, Emile E.
Title Facilitating a culture of responsible and effective sharing of cancer genome data
Journal name Nature Medicine   Check publisher's open access policy
ISSN 1546-170X
1078-8956
Publication date 2016-05-05
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nm.4089
Open Access Status Not Open Access
Volume 22
Issue 5
Start page 464
End page 471
Total pages 8
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Collection year 2017
Language eng
Abstract Rapid and affordable tumor molecular profiling has led to an explosion of clinical and genomic data poised to enhance the diagnosis, prognostication and treatment of cancer. A critical point has now been reached at which the analysis and storage of annotated clinical and genomic information in unconnected silos will stall the advancement of precision cancer care. Information systems must be harmonized to overcome the multiple technical and logistical barriers to data sharing. Against this backdrop, the Global Alliance for Genomic Health (GA4GH) was established in 2013 to create a common framework that enables responsible, voluntary and secure sharing of clinical and genomic data. This Perspective from the GA4GH Clinical Working Group Cancer Task Team highlights the data-aggregation challenges faced by the field, suggests potential collaborative solutions and describes how GA4GH can catalyze a harmonized data-sharing culture.
Keyword Cancer genomics
Computational biology and bioinformatics
Genetic databases
Global Alliance for Genomic Health (GA4GH)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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