Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles

Leite-Silva, Vania R., Liu, David C., Sanchez, Washington Y., Studier, Hauke, Mohammed, Yousuf H., Holmes, Amy, Becker, Wolfgang, Grice, Jeffrey E., Benson, Heather A. E. and Roberts, Michael S. (2016) Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles. Nanomedicine, 11 10: 1193-1205. doi:10.2217/nnm-2016-0010


Author Leite-Silva, Vania R.
Liu, David C.
Sanchez, Washington Y.
Studier, Hauke
Mohammed, Yousuf H.
Holmes, Amy
Becker, Wolfgang
Grice, Jeffrey E.
Benson, Heather A. E.
Roberts, Michael S.
Title Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles
Formatted title
Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles
Journal name Nanomedicine   Check publisher's open access policy
ISSN 1748-6963
1743-5889
Publication date 2016-05-01
Year available 2016
Sub-type Article (original research)
DOI 10.2217/nnm-2016-0010
Open Access Status Not Open Access
Volume 11
Issue 10
Start page 1193
End page 1205
Total pages 13
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2017
Language eng
Formatted abstract
Aim: We assessed the effects of flexing and massage on human skin penetration and toxicity of topically applied coated and uncoated zinc oxide nanoparticles (˜75 nm) in vivo. Materials & methods: Noninvasive multiphoton tomography with fluorescence lifetime imaging was used to evaluate the penetration of nanoparticles through the skin barrier and cellular apoptosis in the viable epidermis. Results: All nanoparticles applied to skin with flexing and massage were retained in the stratum corneum or skin furrows. No significant penetration into the viable epidermis was seen and no cellular toxicity was detected. Conclusion: Exposure of normal in vivo human skin to these nanoparticles under common in-use conditions of flexing or massage is not associated with significant adverse events.
Keyword Flexing
Human skin in vivo
Imaging
Massage
Nanoparticle penetration
Zinc oxide
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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