Reverse immunoediting: when immunity is edited by antigen

Merlo, Anna, Dalla Santa, Silvia, Dolcetti, Riccardo, Zanovello, Paola and Rosato, Antonio (2016) Reverse immunoediting: when immunity is edited by antigen. Immunology Letters, 175 16-20. doi:10.1016/j.imlet.2016.04.015

Author Merlo, Anna
Dalla Santa, Silvia
Dolcetti, Riccardo
Zanovello, Paola
Rosato, Antonio
Title Reverse immunoediting: when immunity is edited by antigen
Journal name Immunology Letters   Check publisher's open access policy
ISSN 1879-0542
Publication date 2016-07-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.imlet.2016.04.015
Open Access Status Not Open Access
Volume 175
Start page 16
End page 20
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2017
Language eng
Abstract Immune selective pressure occurring during cancer immunoediting shapes tumor features revealed at clinical presentation. However, in the "Escape" phase, the tumor itself has the chance to influence the immunological response. Therefore, the capacity of the immune response to sculpt the tumor characteristics is only one side of the coin and even the opposite is likely true, i.e. that an antigen can shape the immune response in a sort of "reverse immunoediting".This reciprocal modeling probably occurs continuously, whenever the immune system encounters a tumor/foreign antigen, and can be operative in the pathogen/immune system interplay, thus possibly permeating the protective immunity as a whole. In line with this view, the characterization of a T cell response as well as the design of both active and passive immunotherapy strategies should also take into account all Ag features (type, load and presentation).Overall, we suggest that the "reverse immunoediting" hypothesis could help to dissect the complex interplay between antigens and the immune repertoire, and to improve the outcome of immunotherapeutic approaches, where T cell responses are manipulated and reprogrammed.
Keyword Antigen
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
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