Neurosensory Impairment after Surgical Closure of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants: Results from the Trial of Indomethacin Prophylaxis in Preterms

Kabra, Nandkishor S., Schmidt, Barbara, Roberts, Robin S., Doyle, Lex W., Papile, Luann and Fanaroff, Avroy (2007) Neurosensory Impairment after Surgical Closure of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants: Results from the Trial of Indomethacin Prophylaxis in Preterms. Journal of Pediatrics, 150 3: 229-234. doi:10.1016/j.jpeds.2006.11.039


Author Kabra, Nandkishor S.
Schmidt, Barbara
Roberts, Robin S.
Doyle, Lex W.
Papile, Luann
Fanaroff, Avroy
Title Neurosensory Impairment after Surgical Closure of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants: Results from the Trial of Indomethacin Prophylaxis in Preterms
Journal name Journal of Pediatrics   Check publisher's open access policy
ISSN 0022-3476
Publication date 2007
Sub-type Article (original research)
DOI 10.1016/j.jpeds.2006.11.039
Volume 150
Issue 3
Start page 229
End page 234
Total pages 1
Language eng
Subject 2735 Pediatrics, Perinatology, and Child Health
Abstract Objectives: To determine whether surgical closure of a patent ductus arteriosus (PDA) is a risk factor for bronchopulmonary dysplasia (BPD), severe retinopathy of prematurity (ROP), and neurosensory impairment in extremely low birth weight (ELBW) infants. Study design: We studied 426 infants with a symptomatic PDA, 110 of whom underwent PDA ligation and 316 of whom received medical therapy only. All infants participated in the multicenter Trial of Indomethacin Prophylaxis in Preterms (TIPP) and were observed to a corrected age of 18 months. Results: Of the 95 infants who survived after PDA ligation, 50 (53%) had neurosensory impairment, compared with 84 of the 245 infants (34%) who survived after receiving only medical therapy (adjusted odds ratio, 1.98; 95% CI, 1.18-3.30; P = .0093). BPD (adjusted odds ratio, 1.81; 95% CI, 1.09-3.03; P = .023) and severe ROP (adjusted odds ratio, 2.20; 95% CI, 1.19-4.07; P = .012) were also more common after surgical PDA closure. Conclusions: PDA ligation may be associated with increased risks of BPD, severe ROP, and neurosensory impairment in ELBW infants.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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