A mutation in the Cdon gene potentiates congenital nevus development mediated by NRASQ61K

Chitsazan, Arash, Ferguson, Blake, Ram, Ramesh, Mukhopadhyay, Pamela, Handoko, Herlina Y., Gabrielli, Brian, Soyer, Peter H, Morahan, Grant and Walker, Graeme J. (2016) A mutation in the Cdon gene potentiates congenital nevus development mediated by NRASQ61K. Pigment Cell and Melanoma Research, 29 4: 459-464. doi:10.1111/pcmr.12487


Author Chitsazan, Arash
Ferguson, Blake
Ram, Ramesh
Mukhopadhyay, Pamela
Handoko, Herlina Y.
Gabrielli, Brian
Soyer, Peter H
Morahan, Grant
Walker, Graeme J.
Title A mutation in the Cdon gene potentiates congenital nevus development mediated by NRASQ61K
Formatted title
A mutation in the Cdon gene potentiates congenital nevus development mediated by NRASQ61K
Journal name Pigment Cell and Melanoma Research   Check publisher's open access policy
ISSN 1755-1471
1755-148X
Publication date 2016-07
Year available 2016
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1111/pcmr.12487
Open Access Status Not Open Access
Volume 29
Issue 4
Start page 459
End page 464
Total pages 14
Place of publication Hoboken, United States
Publisher Wiley-Blackwell Publishing
Collection year 2017
Language eng
Formatted abstract
Congenital nevi develop before birth, and sometimes cover large areas of the body. They are presumed to arise from the acquisition of a gene mutation in an embryonic melanocyte that becomes trapped in the dermis during development. Mice bearing the Cdk4R24C::Tyr-NRASQ61K transgenes develop congenital nevus-like lesions by post natal day 10, from melanocytes escaping the confines of hair follicles. We combined these mice with the Collaborative Cross (CC), a resource that enables identification of modifier genes for complex diseases (those where multiple genes are involved). We examined variation in nevus cell density in 66 CC strains and mapped a large effect quantitative trait locus (QTL) controlling nevus cell density to murine chromosome 9. The best candidate for a gene that exacerbates congenital nevus development in the context of an NRAS mutation is Cdon, a positive regulator of sonic hedgehog (Shh) that is expressed mainly in keratinocytes.
Keyword Congenital naevi
Qtl
Mice
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collections: HERDC Pre-Audit
Admin Only - School of Medicine
School of Medicine Publications
UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Mon, 23 May 2016, 14:53:26 EST by Professor Peter Soyer on behalf of School of Medicine