Microbiota and the nitrogen cycle: implications in the development and progression of CVD and CKD

Briskey, David, Tucker, Patrick S., Johnson, David W. and Coombes, Jeff S. (2016) Microbiota and the nitrogen cycle: implications in the development and progression of CVD and CKD. Nitric Oxide, 57 64-70. doi:10.1016/j.niox.2016.05.002


Author Briskey, David
Tucker, Patrick S.
Johnson, David W.
Coombes, Jeff S.
Title Microbiota and the nitrogen cycle: implications in the development and progression of CVD and CKD
Journal name Nitric Oxide   Check publisher's open access policy
ISSN 1089-8603
1089-8611
Publication date 2016-07-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.niox.2016.05.002
Open Access Status Not Open Access
Volume 57
Start page 64
End page 70
Total pages 7
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2017
Language eng
Abstract Chronic kidney disease (CKD) is associated with an increased risk of death from cardiovascular disease (CVD). One factor involved in CVD development is nitric oxide (NO), which acts as a powerful vasodilator. NO is produced via the nitrogen cycle, through the reduction of nitrate to nitrite with the process mainly occurring in the mouth by commensal microbiota. People with CKD have compromised microbiota (dysbiosis) with an increased abundance of potentially pathogenic and pro-inflammatory bacteria capable of producing uremic toxins that contribute to CKD development and reduce enzymatic NO production. However, to date, few studies have comprehensively documented the gut or saliva microbiota in the CKD population or investigated the role of NO in people with CKD. This review will discuss NO pathways that are linked to the progression of CKD and CVD and therapeutic options for targeting these pathways.
Keyword Nitrate
Nitrite
Nitric oxide
Chronic kidney disease
Cardiovascular disease
Microbiota
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Admin Only - School of Medicine
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
 
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Created: Thu, 19 May 2016, 14:21:33 EST by Dr David Briskey on behalf of School of Human Movement and Nutrition Sciences