Malignant pilomatricoma in a soft-coated Wheaten Terrier

Jackson, Karen, Boger, Lore, Goldschmidt, Michael and Walton, Raquel M. (2010) Malignant pilomatricoma in a soft-coated Wheaten Terrier. Veterinary Clinical Pathology, 39 2: 236-240. doi:10.1111/j.1939-165X.2009.00194.x


Author Jackson, Karen
Boger, Lore
Goldschmidt, Michael
Walton, Raquel M.
Title Malignant pilomatricoma in a soft-coated Wheaten Terrier
Journal name Veterinary Clinical Pathology   Check publisher's open access policy
ISSN 0275-6382
1939-165X
Publication date 2010-06
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1939-165X.2009.00194.x
Open Access Status Not Open Access
Volume 39
Issue 2
Start page 236
End page 240
Total pages 5
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Abstract A 3-year-old, castrated male, soft-coated Wheaten Terrier was presented for evaluation of mild lameness, fecal incontinence, lumbosacral pain, and lack of anal tone. Magnetic resonance imaging scan showed a large (8 × 6 × 5 cm) mass invading and expanding the pelvic bones, sacrum, and associated structures. A fine-needle aspirate of the mass contained many neoplastic cells with high nuclear to cytoplasmic ratios and rare spindle and inflammatory cells. The neoplastic cells were 12-16 μm in diameter, round to cuboidal, basaloid in appearance, and arranged both individually and in loosely cohesive clusters with variably distinct cell borders. Given the location, signalment, and cytologic findings, differential interpretations included a primitive embryonal tumor (eg, neuroblastoma or nephroblastoma in an atypical location) or poorly differentiated carcinoma. The owner elected euthanasia due to the poor prognosis. Abnormal gross findings on necropsy included the pelvic mass and multiple firm, pale, pink-tan nodules in the lung, which proved to be metastases. On histologic examination, the mass and nodules were composed of irregular islands, lobules, and nests of basaloid cells, which transitioned abruptly into large lakes of "ghost" cells with areas of ossification and calcification, consistent with a diagnosis of malignant pilomatricoma. This unusual presentation of a pilomatricoma adds to our knowledge of expected cytologic findings for this tumor.
Keyword Basaloid cell
Canine
Cytology
Malignant pilomatricoma
Pelvic mass
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
 
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Created: Tue, 17 May 2016, 14:55:07 EST by Karen Jackson on behalf of Learning and Research Services (UQ Library)