Lycoperdonosis in two dogs

Alenghat, Theresa, Pillitteri, Cara A., Bemis, David A., Kellett-Gregory, Lindsay, Jackson, Karen V., Kania, Stephen A., Donnell, Robert L. and Van Winkle, Thomas (2010) Lycoperdonosis in two dogs. Journal of Veterinary Diagnostic Investigation, 22 6: 1002-1005. doi:10.1177/104063871002200629


Author Alenghat, Theresa
Pillitteri, Cara A.
Bemis, David A.
Kellett-Gregory, Lindsay
Jackson, Karen V.
Kania, Stephen A.
Donnell, Robert L.
Van Winkle, Thomas
Title Lycoperdonosis in two dogs
Journal name Journal of Veterinary Diagnostic Investigation   Check publisher's open access policy
ISSN 1040-6387
1943-4936
Publication date 2010-11
Sub-type Article (original research)
DOI 10.1177/104063871002200629
Open Access Status Not Open Access
Volume 22
Issue 6
Start page 1002
End page 1005
Total pages 4
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Language eng
Formatted abstract
Lycoperdonosis is a rare respiratory disease that results from the inhalation of spores released from the Lycoperdon (puffball) mushroom. In the present study, 2 cases of confirmed canine lycoperdonosis are described. The first case presented to the Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania, and the second case was submitted for postmortem examination to the University of Tennessee Veterinary Teaching Hospital. Both dogs presented in respiratory distress, and owners reported that the dogs had been playing or digging in areas with puffball mushrooms prior to the onset of clinical signs. In the initial case, thoracic radiographs revealed a diffuse interstitial and multifocal alveolar pulmonary pattern. Despite aggressive medical treatment and mechanical ventilation, the dog continued to worsen and was euthanized. Postmortem examination revealed firm lung lobes and enlarged tracheobronchial lymph nodes. Histologically, there was a severe diffuse histiocytic and pyogranulomatous bronchointerstitial pneumonia. Throughout the lung and lymph nodes, most commonly within macrophages, were round, 3–5 mm in diameter, Gomori methenamine silver–positive structures, consistent with Lycoperdon spores. An approximately 750–base pair DNA fragment was amplified from lung of both cases by polymerase chain reaction using primers specific to yeast ribosomal DNA, and the sequence of the fragment was determined to be most closely related to Lycoperdon pyriforme. Importantly, reexamination of an endotracheal wash from the initial case revealed intrahistiocytic spores, suggesting that airway sampling may assist in diagnosing lycoperdonosis.
Keyword Canine
Lycoperdon
Mushroom
Hypersensitivity Pneumonitis
Spores
Mushrooms
Lungs
Pneumonia
Puffball
Respiratory
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
 
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Created: Tue, 17 May 2016, 14:54:25 EST by Karen Jackson on behalf of Learning and Research Services (UQ Library)