First interim analysis of a randomised trial of whole brain radiotherapy in melanoma brain metastases confirms high data quality

Fogarty, Gerald B, Hong, Angela, Dolven-Jacobsen, Kari, Reisse, Claudius H., Burmeister, Bryan, Haydu, Lauren H., Dhillon, Haryana, Steel, Victoria, Shivalingam, Brindha, Drummond, Kate, Vardy, Janette, Nowak, Anna, Hruby, George, Scolyer, Richard A., Mandel, Catherine and Thompson, John F. (2015) First interim analysis of a randomised trial of whole brain radiotherapy in melanoma brain metastases confirms high data quality. BMC Research Notes, 8 1: . doi:10.1186/s13104-015-1153-5


Author Fogarty, Gerald B
Hong, Angela
Dolven-Jacobsen, Kari
Reisse, Claudius H.
Burmeister, Bryan
Haydu, Lauren H.
Dhillon, Haryana
Steel, Victoria
Shivalingam, Brindha
Drummond, Kate
Vardy, Janette
Nowak, Anna
Hruby, George
Scolyer, Richard A.
Mandel, Catherine
Thompson, John F.
Title First interim analysis of a randomised trial of whole brain radiotherapy in melanoma brain metastases confirms high data quality
Journal name BMC Research Notes   Check publisher's open access policy
ISSN 1756-0500
Publication date 2015-05-08
Sub-type Article (original research)
DOI 10.1186/s13104-015-1153-5
Open Access Status DOI
Volume 8
Issue 1
Total pages 6
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2016
Formatted abstract
Brain metastases are a common cause of death in patients with melanoma. The role of adjuvant whole brain radiotherapy (WBRT) following local treatment of intracranial melanoma metastases is controversial. The Australian and New Zealand Melanoma Trials Group (ANZMTG) and the Trans-Tasman Radiation Oncology Group (TROG) are leading the first ever single histology randomised trial investigating this question. The primary endpoint is distant intracranial failure on magnetic resonance imaging (MRI) within twelve months of randomisation. The first planned interim analysis was performed twelve months after randomisation of the 100th patient. The analysis was an opportunity to review completeness of the trial data to date.
Keyword Brain
Melanoma
Metastases
Radiotherapy
Randomised trial
Whole brain radiotherapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
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