Controlling mesoporous silica-coating of layered double hydroxide nanoparticles for drug control release

Harrison, Ryan, Li, Li, Gu, Zi and Xu, Zhi Ping (2016) Controlling mesoporous silica-coating of layered double hydroxide nanoparticles for drug control release. Microporous and Mesoporous Materials, 238 97-104. doi:10.1016/j.micromeso.2016.04.031


Author Harrison, Ryan
Li, Li
Gu, Zi
Xu, Zhi Ping
Title Controlling mesoporous silica-coating of layered double hydroxide nanoparticles for drug control release
Journal name Microporous and Mesoporous Materials   Check publisher's open access policy
ISSN 1387-1811
1873-3093
Publication date 2016-04-23
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.micromeso.2016.04.031
Open Access Status Not yet assessed
Volume 238
Start page 97
End page 104
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2017
Language eng
Formatted abstract
Layered double hydroxide (LDH) nanoparticles (NPs) have found various potential applications in control delivery of therapeutics, including many negatively charged drugs, oligonucleotides, genes, and peptides/proteins. The current study specifically investigated the surface coating with mesoporous silica (mSiO2) to make an LDH@mSiO2 core/shell structure and precisely control the release of the payload. Mg2Al-LDH NPs were coated with mSiO2 by varying the reagent concentration and the chain length of cationic surfactants in order to tailor the thickness and the pore size of the mSiO2 shell. TEM images and FTIR spectra evidenced the successful mSiO2 coating onto the surface of LDH NPs. Within the tested conditions, the thickness of the mSiO2 shell can be tailored from 5 to 20 nm and the pore size from 1.9 to 3.3 nm. We further demonstrated that the exchanging property of Mg2Al-Cl-LDH NPs, combined with the diffusion control of the mSiO2 shell, resulted in an effective controlled release of the payload. Thus we have established a foundation for the development of a multifunctional smart delivery platform.
Keyword Control release
Drug delivery system
Layered double hydroxide nanoparticle
Mesoporous silica
Surface coating
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
 
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