Genetic and environmental contributions to functional connectivity architecture of the human brain

Yang, Zhi, Zuo, Xi-Nian, McMahon, Katie L., Craddock, R. Cameron, Kelly, Clare, de Zubicaray, Greig I., Hickie, Ian, Bandettini, Peter A., Castellanos, F. Xavier, Milham, Michael P. and Wright, Margaret J. (2016) Genetic and environmental contributions to functional connectivity architecture of the human brain. Cerebral Cortex, 26 5: 2341-2352. doi:10.1093/cercor/bhw027

Author Yang, Zhi
Zuo, Xi-Nian
McMahon, Katie L.
Craddock, R. Cameron
Kelly, Clare
de Zubicaray, Greig I.
Hickie, Ian
Bandettini, Peter A.
Castellanos, F. Xavier
Milham, Michael P.
Wright, Margaret J.
Title Genetic and environmental contributions to functional connectivity architecture of the human brain
Journal name Cerebral Cortex   Check publisher's open access policy
ISSN 1460-2199
Publication date 2016-05-01
Year available 2016
Sub-type Article (original research)
DOI 10.1093/cercor/bhw027
Open Access Status Not Open Access
Volume 26
Issue 5
Start page 2341
End page 2352
Total pages 12
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2017
Language eng
Abstract One of the grand challenges faced by neuroscience is to delineate the determinants of interindividual variation in the comprehensive structural and functional connection matrices that comprise the human connectome. At present, this endeavor appears most tractable at the macroanatomic scale, where intrinsic brain activity exhibits robust patterns of synchrony that recapitulate core functional circuits at the individual level. Here, we use a classical twin study design to examine the heritability of intrinsic functional network properties in 101 twin pairs, including network activity (i.e., variance of a network's specific temporal fluctuations) and internetwork coherence (i.e., correlation between networks' specific temporal fluctuations). Five of 7 networks exhibited significantly heritable (23.3–65.2%) network activity, 6 of the 21 internetwork coherences were significantly heritable (25.6–42.0%), and 11 of the 21 internetwork coherences were significantly influenced by common environmental factors (18.0–47.1%). These results suggest that the source of interindividual variation in functional connectome has a modular architecture: individual modules represented by intrinsic connectivity networks are genetic controlled, while environmental factors influence the interplays between the modules. This work further provides network-specific hypotheses for discovery of the specific genetic and environmental factors influencing functional specialization and integration of the human brain.
Keyword Connectome
Environmental contribution
Intrinsic connectivity network
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Psychology Publications
Centre for Advanced Imaging Publications
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