Is there a role for microsampling in antibiotic pharmacokinetic studies?

Parker, Suzanne L., Dorofaeff, Tavey, Lipman, Jeffrey, Ballot, Daynia E., Bandini, Rossella M., Wallis, Steven C. and Roberts, Jason A. (2016) Is there a role for microsampling in antibiotic pharmacokinetic studies?. Expert Opinion on Drug Metabolism and Toxicology, 12 6: 601-614. doi:10.1080/17425255.2016.1178238

Author Parker, Suzanne L.
Dorofaeff, Tavey
Lipman, Jeffrey
Ballot, Daynia E.
Bandini, Rossella M.
Wallis, Steven C.
Roberts, Jason A.
Title Is there a role for microsampling in antibiotic pharmacokinetic studies?
Journal name Expert Opinion on Drug Metabolism and Toxicology   Check publisher's open access policy
ISSN 1744-7607
Publication date 2016-05-03
Year available 2016
Sub-type Article (original research)
DOI 10.1080/17425255.2016.1178238
Open Access Status Not Open Access
Volume 12
Issue 6
Start page 601
End page 614
Total pages 14
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Collection year 2017
Language eng
Formatted abstract
Introduction: Clinical pharmacokinetic studies of antibiotics can establish evidence-based dosing regimens that improve the likelihood of eradicating the pathogen at the site of infection, reduce the potential for selection of resistant pathogens, and minimize harm to the patient. Innovations in small volume sampling (< 50 μL) or ‘microsampling’ may result in less-invasive sample collection, self-sampling and dried storage. Microsampling may open up opportunities in patient groups where sampling is challenging.

Areas Covered: The challenges for implementation of microsampling to assure suitability of the results, include: acceptable study design, regulatory agency acceptance, and meeting bioanalytical validation requirements. This manuscript covers various microsampling methods, including dried blood/plasma spots, volumetric absorptive microsampling, capillary microsampling, plasma preparation technologies and solid-phase microextraction.

Expert Opinion: The available analytical technology is being underutilized due to a lack of bridging studies and validated bioanalytical methods. These deficiencies represent major impediments to the application of microsampling to antibiotic pharmacokinetic studies. A conceptual framework for the assessment of the suitability of microsampling in clinical pharmacokinetic studies of antibiotics is provided. This model establishes a ‘contingency approach’ with consideration of the antibiotic and the type and location of the patient, as well as the more prescriptive bioanalytical validation protocols.
Keyword Antibiotic
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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