The role of rumen-protected choline in hepatic function and performance of transition dairy cows

Shahsavari, Arash, D'Occhio, Michael J. and Al Jassim, Rafat (2016) The role of rumen-protected choline in hepatic function and performance of transition dairy cows. British Journal of Nutrition, 116 1: 35-44. doi:10.1017/S0007114516001641

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Author Shahsavari, Arash
D'Occhio, Michael J.
Al Jassim, Rafat
Title The role of rumen-protected choline in hepatic function and performance of transition dairy cows
Journal name British Journal of Nutrition   Check publisher's open access policy
ISSN 1475-2662
0007-1145
Publication date 2016-07
Year available 2016
Sub-type Article (original research)
DOI 10.1017/S0007114516001641
Open Access Status File (Publisher version)
Volume 116
Issue 1
Start page 35
End page 44
Total pages 10
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2017
Language eng
Abstract High-producing dairy cows enter a period of negative energy balance during the first weeks of lactation. Energy intake is usually sufficient to cover the increase in energy requirements for fetal growth during the period before calving, but meeting the demand for energy is often difficult during the early stages of lactation. A catabolic state predominates during the transition period, leading to the mobilisation of energy reserves (NEFA and amino acids) that are utilised mainly by the liver and muscle. Increased uptake of mobilised NEFA by the liver, combined with the limited capacity of hepatocytes to either oxidise fatty acids for energy or to incorporate esterified fatty acids into VLDL results in fatty liver syndrome and ketosis. This metabolic disturbance can affect the general health, and it causes economic losses. Different nutritional strategies have been used to restrict negative effects associated with the energy challenge in transition cows. The provision of choline in the form of rumen-protected choline (RPC) can potentially improve liver function by increasing VLDL exportation from the liver. RPC increases gene expression of microsomal TAG transfer protein and APOB100 that are required for VLDL synthesis and secretion. Studies with RPC have looked at gene expression, metabolic hormones, metabolite profiles, milk production and postpartum reproduction. A reduction in liver fat and enhanced milk production has been observed with RPC supplementation. However, the effects of RPC on health and reproduction are equivocal, which could reflect the lack of sufficient dose–response studies.
Keyword Transition dairy cows
Rumen-protected choline
Liver
Fatty liver syndrome
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Agriculture and Food Sciences
 
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