The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children

Zhou, Zhi-yong, Yang, Yi-de, Wang, Shuo, Dong, Bin, Li, Xiao-hui and Ma, Jun (2016) The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children. British Journal of Nutrition, 116 1: 45-51. doi:10.1017/S0007114516001744


Author Zhou, Zhi-yong
Yang, Yi-de
Wang, Shuo
Dong, Bin
Li, Xiao-hui
Ma, Jun
Title The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children
Journal name British Journal of Nutrition   Check publisher's open access policy
ISSN 1475-2662
0007-1145
Publication date 2016-07
Sub-type Article (original research)
DOI 10.1017/S0007114516001744
Volume 116
Issue 1
Start page 45
End page 51
Total pages 7
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2017
Language eng
Formatted abstract
We aimed to examine the contribution of blood lipids to the association between BMI and blood pressure (BP) in children with overweight and obesity. Data were collected in elementary and high schools of Chaoyang District, Beijing, China in 2012. Participants’ weight, height, BP and fasting plasma lipid profile were measured by standard protocols. Mediation analysis was used to examine the mediation role of blood lipids on the relation between BMI and BP, with age included as a covariate. We found that in boys 8·29 % (mediation effect=0·106, P=0·012) of the association between BMI and systolic BP was mediated through TAG. TAG mediated 12·53 % (mediation effect=0·093, P=0·018) and LDL-cholesterol mediated 7·75 % (mediation effect=0·57, P=0·046) of the association between BMI and diastolic BP was mediated by TAG and LDL-cholesterol, respectively. However, blood lipids did not show the mediation effect in girls. Our findings suggested that there was a sex difference in the contribution of blood lipids to the association between BMI and BP. Controlling TAG or LDL-cholesterol may be beneficial for reducing the risk of the BMI-related high BP in overweight boys; however, this outcome is not the case when controlling TAG or LDL-cholesterol in girls. This study may provide clues to explore the underlying mechanism of the association between obesity and hypertension.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Sun, 15 May 2016, 13:32:57 EST by Bin Dong on behalf of Medicine - Royal Brisbane and Women's Hospital