TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

Ullah, M. Obayed, Sweet, Matthew J., Mansell, Ashley, Kellie, Stuart and Kobe, Bostjan (2016) TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target. Journal of Leukocyte Biology, 100 1: 27-45. doi:10.1189/jlb.2RI1115-531R


Author Ullah, M. Obayed
Sweet, Matthew J.
Mansell, Ashley
Kellie, Stuart
Kobe, Bostjan
Title TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target
Journal name Journal of Leukocyte Biology   Check publisher's open access policy
ISSN 0741-5400
1938-3673
Publication date 2016-05-09
Year available 2016
Sub-type Article (original research)
DOI 10.1189/jlb.2RI1115-531R
Open Access Status Not Open Access
Volume 100
Issue 1
Start page 27
End page 45
Total pages 19
Place of publication Bethesda, United States
Publisher Federation of American Societies for Experimental Biology
Collection year 2017
Language eng
Formatted abstract
Toll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF)-dependent signaling is required for TLR-mediated production of type-I IFN and several other proinflammatory mediators. Various pathogens target the signaling molecules and transcriptional regulators acting in the TRIF pathway, thus demonstrating the importance of this pathway in host defense. Indeed, the TRIF pathway contributes to control of both viral and bacterial pathogens through promotion of inflammatory mediators and activation of antimicrobial responses. TRIF signaling also has both protective and pathologic roles in several chronic inflammatory disease conditions, as well as an essential function in wound-repair processes. Here, we review our current understanding of the regulatory mechanisms that control TRIF-dependent TLR signaling, the role of the TRIF pathway in different infectious and noninfectious pathologic states, and the potential for manipulating TRIF-dependent TLR signaling for therapeutic benefit.
Keyword Adaptor protein
Innate immunity
Pattern recognition receptor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 13 May 2016, 14:56:00 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences